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Target
DNA polymerase catalytic subunit
Ligand
BDBM50210613
Substrate
n/a
Meas. Tech.
ChEMBL_455453 (CHEMBL886229)
IC50
1580±n/a nM
Citation
 Schnute, ME; Anderson, DJ; Brideau, RJ; Ciske, FL; Collier, SA; Cudahy, MM; Eggen, M; Genin, MJ; Hopkins, TA; Judge, TM; Kim, EJ; Knechtel, ML; Nair, SK; Nieman, JA; Oien, NL; Scott, A; Tanis, SP; Vaillancourt, VA; Wathen, MW; Wieber, JL 2-Aryl-2-hydroxyethylamine substituted 4-oxo-4,7-dihydrothieno[2,3-b]pyridines as broad-spectrum inhibitors of human herpesvirus polymerases. Bioorg Med Chem Lett 17:3349-53 (2007) [PubMed]  Article 
Target
Name:
DNA polymerase catalytic subunit
Synonyms:
DNA polymerase | DPOL_HCMVA | HFLF2 | Human herpesvirus 5 DNA polymerase | UL54
Type:
Protein
Mol. Mass.:
137111.39
Organism:
Human cytomegalovirus (HCMV strain AD169)
Description:
P08546
Residue:
1242
Sequence:
MFFNPYLSGGVTGGAVAGGRRQRSQPGSAQGSGKRPPQKQFLQIVPRGVMFDGQTGLIKHKTGRLPLMFYREIKHLLSHDMVWPCPWRETLVGRVVGPIRFHTYDQTDAVLFFDSPENVSPRYRQHLVPSGNVLRFFGATEHGYSICVNVFGQRSYFYCEYSDTDRLREVIASVGELVPEPRTPYAVSVTPATKTSIYGYGTRPVPDLQCVSISNWTMARKIGEYLLEQGFPVYEVRVDPLTRLVIDRRITTFGWCSVNRYDWRQQGRASTCDIEVDCDVSDLVAVPDDSSWPRYRCLSFDIECMSGEGGFPCAEKSDDIVIQISCVCYETGGNTAVDQGIPNGNDGRGCTSEGVIFGHSGLHLFTIGTCGQVGPDVDVYEFPSEYELLLGFMLFFQRYAPAFVTGYNINSFDLKYILTRLEYLYKVDSQRFCKLPTAQGGRFFLHSPAVGFKRQYAAAFPSASHNNPASTAATKVYIAGSVVIDMYPVCMAKTNSPNYKLNTMAELYLRQRKDDLSYKDIPRCFVANAEGRAQVGRYCLQDAVLVRDLFNTINFHYEAGAIARLAKIPLRRVIFDGQQIRIYTSLLDECACRDFILPNHYSKGTTVPETNSVAVSPNAAIISTAAVPGDAGSVAAMFQMSPPLQSAPSSQDGVSPGSGSNSSSSVGVFSVGSGSSGGVGVSNDNHGAGGTAAVSYQGATVFEPEVGYYNDPVAVFDFASLYPSIIMAHNLCYSTLLVPGGEYPVDPADVYSVTLENGVTHRFVRASVRVSVLSELLNKWVSQRRAVRECMRECQDPVRRMLLDKEQMALKVTCNAFYGFTGVVNGMMPCLPIAASITRIGRDMLERTARFIKDNFSEPCFLHNFFNQEDYVVGTREGDSEESSALPEGLETSSGGSNERRVEARVIYGDTDSVFVRFRGLTPQALVARGPSLAHYVTACLFVEPVKLEFEKVFVSLMMICKKRYIGKVEGASGLSMKGVDLVRKTACEFVKGVTRDVLSLLFEDREVSEAAVRLSRLSLDEVKKYGVPRGFWRILRRLVQARDDLYLHRVRVEDLVLSSVLSKDISLYRQSNLPHIAVIKRLAARSEELPSVGDRVFYVLTAPGVRTAPQGSSDNGDSVTAGVVSRSDAIDGTDDDADGGGVEESNRRGGEPAKKRARKPPSAVCNYEVAEDPSYVREHGVPIHADKYFEQVLKAVTNVLSPVFPGGETARKDKFLHMVLPRRLHLEPAFLPYSVKAHECC
  
Inhibitor
Name:
BDBM50210613
Synonyms:
CHEMBL391831 | N-(4-chlorobenzyl)-2-(((2-hydroxy-2-phenylethyl)(2-hydroxyethyl)amino)methyl)-7-methyl-4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamide
Type:
Small organic molecule
Emp. Form.:
C27H28ClN3O4S
Mol. Mass.:
526.047
SMILES:
Cn1cc(C(=O)NCc2ccc(Cl)cc2)c(=O)c2cc(CN(CCO)CC(O)c3ccccc3)sc12 |w:26.27|
Structure:
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