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Target
Polyphenol oxidase 2
Ligand
BDBM50218210
Substrate
n/a
Meas. Tech.
ChEMBL_457051 (CHEMBL923387)
IC50
18080±n/a nM
Citation
 Casañola-Martín, GM; Marrero-Ponce, Y; Khan, MT; Ather, A; Khan, KM; Torrens, F; Rotondo, R Dragon method for finding novel tyrosinase inhibitors: Biosilico identification and experimental in vitro assays. Eur J Med Chem 42:1370-81 (2007) [PubMed]  Article 
Target
Name:
Polyphenol oxidase 2
Synonyms:
Monophenol monooxygenase | Monophenol oxidase | PPO2 | PPO2_AGABI | Tyrosinase
Type:
Protein
Mol. Mass.:
63923.66
Organism:
Agaricus bisporus (Common mushroom)
Description:
O42713
Residue:
556
Sequence:
MSLIATVGPTGGVKNRLNIVDFVKNEKFFTLYVRSLELLQAKEQHDYSSFFQLAGIHGLPFTEWAKERPSMNLYKAGYCTHGQVLFPTWHRTYLSVLEQILQGAAIEVAKKFTSNQTDWVQAAQDLRQPYWDWGFELMPPDEVIKNEEVNITNYDGKKISVKNPILRYHFHPIDPSFKPYGDFATWRTTVRNPDRNRREDIPGLIKKMRLEEGQIREKTYNMLKFNDAWERFSNHGISDDQHANSLESVHDDIHVMVGYGKIEGHMDHPFFAAFDPIFWLHHTNVDRLLSLWKAINPDVWVTSGRNRDGTMGIAPNAQINSETPLEPFYQSGDKVWTSASLADTARLGYSYPDFDKLVGGTKELIRDAIDDLIDERYGSKPSSGARNTAFDLLADFKGITKEHKEDLKMYDWTIHVAFKKFELKESFSLLFYFASDGGDYDQENCFVGSINAFRGTAPETCANCQDNENLIQEGFIHLNHYLARDLESFEPQDVHKFLKEKGLSYKLYSRGDKPLTSLSVKIEGRPLHLPPGEHRPKYDHTQARVVFDDVAVHVIN
  
Inhibitor
Name:
BDBM50218210
Synonyms:
2,2,2-trifluoro-1-(4-(piperidin-1-yl)piperidin-1-yl)ethanone | CHEMBL250968 | Tyrosinase Inhibitor, 6
Type:
Small organic molecule
Emp. Form.:
C12H19F3N2O
Mol. Mass.:
264.2873
SMILES:
FC(F)(F)C(=O)N1CCC(CC1)N1CCCCC1
Structure:
Search PDB for entries with ligand similarity: