Reaction Details Report a problem with these data
Target
HTH-type transcriptional regulator ExsA
Ligand
BDBM50371226
Substrate
n/a
Meas. Tech.
ChEMBL_457358 (CHEMBL940949)
IC50
4000±n/a nM
Citation
 Bowser, TE; Bartlett, VJ; Grier, MC; Verma, AK; Warchol, T; Levy, SB; Alekshun, MN Novel anti-infection agents: small-molecule inhibitors of bacterial transcription factors. Bioorg Med Chem Lett 17:5652-5 (2007) [PubMed]  Article 
Target
Name:
HTH-type transcriptional regulator ExsA
Synonyms:
EXSA_PSEAE | Exoenzyme S synthesis regulatory protein exsA | exsA
Type:
PROTEIN
Mol. Mass.:
31648.37
Organism:
Pseudomonas aeruginosa
Description:
ChEMBL_635526
Residue:
278
Sequence:
MQGAKSLGRKQITSCHWNIPTFEYRVNKEEGVYVLLEGELTVQDIDSTFCLAPGELLFVRRGSYVVSTKGKDSRILWIPLSAQFLQGFVQRFGALLSEVERCDEPVPGIIAFAATPLLAGCVKGLKELLVHEHPPMLACLKIEELLMLFAFSPQGPLLMSVLRQLSNRHVERLQLFMEKHYLNEWKLSDFSREFGMGLTTFKELFGSVYGVSPRAWISERRILYAHQLLLNSDMSIVDIAMEAGFSSQSYFTQSYRRRFGCTPSRSRQGKDECRAKNN
  
Inhibitor
Name:
BDBM50371226
Synonyms:
CHEMBL251209
Type:
Small organic molecule
Emp. Form.:
C20H13FN4O4
Mol. Mass.:
392.34
SMILES:
On1c(nc2ccc(cc12)[N+]([O-])=O)-c1ccc(NC(=O)c2ccc(F)cc2)cc1
Structure:
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