Reaction Details Report a problem with these data
Target
HTH-type transcriptional regulator ExsA
Ligand
BDBM50371227
Substrate
n/a
Meas. Tech.
ChEMBL_457358 (CHEMBL940949)
IC50
1900±n/a nM
Citation
 Bowser, TE; Bartlett, VJ; Grier, MC; Verma, AK; Warchol, T; Levy, SB; Alekshun, MN Novel anti-infection agents: small-molecule inhibitors of bacterial transcription factors. Bioorg Med Chem Lett 17:5652-5 (2007) [PubMed]  Article 
Target
Name:
HTH-type transcriptional regulator ExsA
Synonyms:
EXSA_PSEAE | Exoenzyme S synthesis regulatory protein exsA | exsA
Type:
PROTEIN
Mol. Mass.:
31648.37
Organism:
Pseudomonas aeruginosa
Description:
ChEMBL_635526
Residue:
278
Sequence:
MQGAKSLGRKQITSCHWNIPTFEYRVNKEEGVYVLLEGELTVQDIDSTFCLAPGELLFVRRGSYVVSTKGKDSRILWIPLSAQFLQGFVQRFGALLSEVERCDEPVPGIIAFAATPLLAGCVKGLKELLVHEHPPMLACLKIEELLMLFAFSPQGPLLMSVLRQLSNRHVERLQLFMEKHYLNEWKLSDFSREFGMGLTTFKELFGSVYGVSPRAWISERRILYAHQLLLNSDMSIVDIAMEAGFSSQSYFTQSYRRRFGCTPSRSRQGKDECRAKNN
  
Inhibitor
Name:
BDBM50371227
Synonyms:
CHEMBL400462
Type:
Small organic molecule
Emp. Form.:
C22H19N5O4
Mol. Mass.:
417.4174
SMILES:
CN(C)c1ccc(cc1)C(=O)Nc1ccc(cc1)-c1nc2ccc(cc2n1O)[N+]([O-])=O
Structure:
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