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Target
Cytochrome P450 1B1
Ligand
BDBM50214610
Substrate
n/a
Meas. Tech.
ChEMBL_459098 (CHEMBL926266)
IC50
11±n/a nM
Citation
 Bruno, RD; Njar, VC Targeting cytochrome P450 enzymes: a new approach in anti-cancer drug development. Bioorg Med Chem 15:5047-60 (2007) [PubMed]  Article 
Target
Name:
Cytochrome P450 1B1
Synonyms:
CP1B1_HUMAN | CYP1B1 | CYPIB1 | Cytochrome P450 1B1 (CYP1B1)
Type:
PROTEIN
Mol. Mass.:
60861.81
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1474523
Residue:
543
Sequence:
MGTSLSPNDPWPLNPLSIQQTTLLLLLSVLATVHVGQRLLRQRRRQLRSAPPGPFAWPLIGNAAAVGQAAHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPAFASFRVVSGGRSMAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALLVRGSADGAFLDPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSLVDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSAEKKAAGDSHGGGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPLKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISILAHQCDFRANPNEPAKMNFSYGLTIKPKSFKVNVTLRESMELLDSAVQNLQAKETCQ
  
Inhibitor
Name:
BDBM50214610
Synonyms:
3,3',4,4',5-Pentachlorobiphenyl | 3,3',4,4',5-pentachloro-1,1'-biphenyl | 3,4,3',4',5'-Pentachlorobiphenyl | 3,4,5,3',4'-Penta coplanar polychlorinated biphenyl | 3,4,5,3',4'-Pentachlorobiphenyl | CHEMBL342696 | PCB 126
Type:
Small organic molecule
Emp. Form.:
C12H5Cl5
Mol. Mass.:
326.433
SMILES:
Clc1ccc(cc1Cl)-c1cc(Cl)c(Cl)c(Cl)c1
Structure:
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