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Target
Tumor susceptibility gene 101 protein
Ligand
BDBM50230448
Substrate
n/a
Meas. Tech.
ChEMBL_461905 (CHEMBL944752)
IC50
22000±n/a nM
Citation
 Liu, F; Stephen, AG; Fisher, RJ; Burke, TR Protected aminooxyprolines for expedited library synthesis: application to Tsg101-directed proline-oxime containing peptides. Bioorg Med Chem Lett 18:1096-101 (2008) [PubMed]  Article 
Target
Name:
Tumor susceptibility gene 101 protein
Synonyms:
TS101_HUMAN | TSG101
Type:
PROTEIN
Mol. Mass.:
43943.30
Organism:
Homo sapiens (Human)
Description:
ChEMBL_800321
Residue:
390
Sequence:
MAVSESQLKKMVSKYKYRDLTVRETVNVITLYKDLKPVLDSYVFNDGSSRELMNLTGTIPVPYRGNTYNIPICLWLLDTYPYNPPICFVKPTSSMTIKTGKHVDANGKIYLPYLHEWKHPQSDLLGLIQVMIVVFGDEPPVFSRPISASYPPYQATGPPNTSYMPGMPGGISPYPSGYPPNPSGYPGCPYPPGGPYPATTSSQYPSQPPVTTVGPSRDGTISEDTIRASLISAVSDKLRWRMKEEMDRAQAELNALKRTEEDLKKGHQKLEEMVTRLDQEVAEVDKNIELLKKKDEELSSALEKMENQSENNDIDEVIIPTAPLYKQILNLYAEENAIEDTIFYLGEALRRGVIDLDVFLKHVRLLSRKQFQLRALMQKARKTAGLSDLY
  
Inhibitor
Name:
BDBM50230448
Synonyms:
(4S)-4-{[(1S)-1-carbamoyl-3-carboxypropyl]carbamoyl}-4-{[(2S,3S)-1-({1-[(2S)-2-[(2S,3R)-2-{[(2S)-1-[(2S)-4-carboxy-2-{[(2S)-1-{5-[({3',6'-dihydroxy-3-oxo-3H-spiro[2-benzofuran-1,9'-xanthene]-6-yl}carbamothioyl)amino]pentanoyl}pyrrolidin-2-yl]formamido}butanoyl]pyrrolidin-2-yl]formamido}-3-hydroxybutanamido]propanoyl]piperidin-2-yl}carbonyl)-3-{[(Z)-[(3,4-dimethoxyphenyl)methylidene]amino]oxy}pyrrolidin-2-yl]formamido}butanoic acid | CHEMBL253262
Type:
Small organic molecule
Emp. Form.:
C78H95N13O25S
Mol. Mass.:
1646.726
SMILES:
COc1ccc(\C=N/O[C@H]2CCN([C@@H]2C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(N)=O)C(=O)C2CCCCN2C(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]2CCCN2C(=O)CCCCNC(=S)Nc2ccc3C(=O)OC4(c3c2)c2ccc(O)cc2Oc2cc(O)ccc42)[C@@H](C)O)cc1OC
Structure:
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