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Target
C-X-C chemokine receptor type 2
Ligand
BDBM50236303
Substrate
n/a
Meas. Tech.
ChEMBL_462972 (CHEMBL928890)
IC50
3000±n/a nM
Citation
 Winters, MP; Crysler, C; Subasinghe, N; Ryan, D; Leong, L; Zhao, S; Donatelli, R; Yurkow, E; Mazzulla, M; Boczon, L; Manthey, CL; Molloy, C; Raymond, H; Murray, L; McAlonan, L; Tomczuk, B Carboxylic acid bioisosteres acylsulfonamides, acylsulfamides, and sulfonylureas as novel antagonists of the CXCR2 receptor. Bioorg Med Chem Lett 18:1926-30 (2008) [PubMed]  Article 
Target
Name:
C-X-C chemokine receptor type 2
Synonyms:
CD_antigen=CD182 | CXC-R2 | CXCR-2 | CXCR2 | CXCR2_RABIT | GRO/MGSA receptor | High affinity interleukin-8 receptor B | IL-8R B | IL8RB
Type:
PROTEIN
Mol. Mass.:
40639.60
Organism:
Oryctolagus cuniculus
Description:
ChEMBL_462972
Residue:
358
Sequence:
MQEFTWENYSYEDFFGDFSNYSYSTDLPPTLLDSAPCRSESLETNSYVVLITYILVFLLSLLGNSLVMLVILYSRSTCSVTDVYLLNLAIADLLFATTLPIWAASKVHGWTFGTPLCKVVSLVKEVNFYSGILLLACISVDRYLAIVHATRTMIQKRHLVKFICLSMWGVSLILSLPILLFRNAIFPPNSSPVCYEDMGNSTAKWRMVLRILPQTFGFILPLLVMLFCYVFTLRTLFQAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLTDTLMRTHVIQETCERRNDIDRALDATEILGFLHSCLNPIIYAFIGQKFRYGLLKILAAHGLISKEFLAKESRPSFVASSSGNTSTTL
  
Inhibitor
Name:
BDBM50236303
Synonyms:
4-(5-cyano-2-(4-fluorophenyl)-1H-indol-3-yl)-N-(trifluoromethylsulfonyl)butanamide | CHEMBL257178
Type:
Small organic molecule
Emp. Form.:
C20H15F4N3O3S
Mol. Mass.:
453.41
SMILES:
Fc1ccc(cc1)-c1[nH]c2ccc(cc2c1CCCC(=O)NS(=O)(=O)C(F)(F)F)C#N
Structure:
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