Reaction Details Report a problem with these data
Target
Cholinesterase
Ligand
BDBM50233374
Substrate
n/a
Meas. Tech.
ChEMBL_463760 (CHEMBL932017)
IC50
9.9±n/a nM
Citation
Fang, L; Appenroth, D; Decker, M; Kiehntopf, M; Roegler, C; Deufel, T; Fleck, C; Peng, S; Zhang, Y; Lehmann, J Synthesis and biological evaluation of NO-donor-tacrine hybrids as hepatoprotective anti-Alzheimer drug candidates. J Med Chem 51:713-6 (2008) [PubMed] Article
More Info.:
Target
Name:
Cholinesterase
Synonyms:
Acylcholine acylhydrolase | BCHE | Butyrylcholine esterase (BChE) | Butyrylcholinesterase (BChE) | Butyrylcholinesterase (BuChE) | CHE1 | CHLE_HUMAN | Choline esterase II | Cholinesterases | Cholinesterases; ACHE & BCHE | Pseudocholinesterase
Type:
Homotetramer
Mol. Mass.:
68422.27
Organism:
Homo sapiens (Human)
Description:
P06276
Residue:
602
Sequence:
MHSKVTIICIRFLFWFLLLCMLIGKSHTEDDIIIATKNGKVRGMNLTVFGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSDIWNATKYANSCCQNIDQSFPGFHGSEMWNPNTDLSEDCLYLNVWIPAPKPKNATVLIWIYGGGFQTGTSSLHVYDGKFLARVERVIVVSMNYRVGALGFLALPGNPEAPGNMGLFDQQLALQWVQKNIAAFGGNPKSVTLFGESAGAASVSLHLLSPGSHSLFTRAILQSGSFNAPWAVTSLYEARNRTLNLAKLTGCSRENETEIIKCLRNKDPQEILLNEAFVVPYGTPLSVNFGPTVDGDFLTDMPDILLELGQFKKTQILVGVNKDEGTAFLVYGAPGFSKDNNSIITRKEFQEGLKIFFPGVSEFGKESILFHYTDWVDDQRPENYREALGDVVGDYNFICPALEFTKKFSEWGNNAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRDNYTKAEEILSRSIVKRWANFAKYGNPNETQNNSTSWPVFKSTEQKYLTLNTESTRIMTKLRAQQCRFWTSFFPKVLEMTGNIDEAEWEWKAGFHRWNNYMMDWKNQFNDYTSKKESCVGL
Inhibitor
Name:
BDBM50233374
Synonyms:
9-[N-gamma-(3'-(nitrooxy)propyl)-gamma-aminobutylamino]-1,2,3,4-tetrahydroacridine | CHEMBL407320 | N-(3-Nitrooxy-propyl)-N'-(1,2,3,4-tetrahydro-acridin-9-yl)-butane-1,4-diamine
Type:
Small organic molecule
Emp. Form.:
C20H28N4O3
Mol. Mass.:
372.4613
SMILES:
[O-][N+](=O)OCCCNCCCCNc1c2CCCCc2nc2ccccc12