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Target
Cathepsin E
Ligand
BDBM50372198
Substrate
n/a
Meas. Tech.
ChEMBL_464803 (CHEMBL946842)
Ki
5±n/a nM
Citation
 Iserloh, U; Wu, Y; Cumming, JN; Pan, J; Wang, LY; Stamford, AW; Kennedy, ME; Kuvelkar, R; Chen, X; Parker, EM; Strickland, C; Voigt, J Potent pyrrolidine- and piperidine-based BACE-1 inhibitors. Bioorg Med Chem Lett 18:414-7 (2008) [PubMed]  Article 
Target
Name:
Cathepsin E
Synonyms:
3.4.23.34 | CATE_HUMAN | CTSE | Cathepsin E form I | Cathepsin E form II
Type:
Enzyme
Mol. Mass.:
43298.99
Organism:
Homo sapiens (Human)
Description:
P14091
Residue:
396
Sequence:
MKTLLLLLLVLLELGEAQGSLHRVPLRRHPSLKKKLRARSQLSEFWKSHNLDMIQFTESCSMDQSAKEPLINYLDMEYFGTISIGSPPQNFTVIFDTGSSNLWVPSVYCTSPACKTHSRFQPSQSSTYSQPGQSFSIQYGTGSLSGIIGADQVSVEGLTVVGQQFGESVTEPGQTFVDAEFDGILGLGYPSLAVGGVTPVFDNMMAQNLVDLPMFSVYMSSNPEGGAGSELIFGGYDHSHFSGSLNWVPVTKQAYWQIALDNIQVGGTVMFCSEGCQAIVDTGTSLITGPSDKIKQLQNAIGAAPVDGEYAVECANLNVMPDVTFTINGVPYTLSPTAYTLLDFVDGMQFCSSGFQGLDIHPPAGPLWILGDVFIRQFYSVFDRGNNRVGLAPAVP
  
Inhibitor
Name:
BDBM50372198
Synonyms:
CHEMBL270359
Type:
Small organic molecule
Emp. Form.:
C35H43F2N3O4
Mol. Mass.:
607.7304
SMILES:
CCCN(CCC)C(=O)c1cc(C)cc(c1)C(=O)N[C@@H](Cc1cc(F)cc(F)c1)[C@H](O)[C@H]1C[C@H](CN1)OCc1ccccc1 |r|
Structure:
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