Reaction Details Report a problem with these data
Target
Histone deacetylase 1
Ligand
BDBM50187086
Substrate
n/a
Meas. Tech.
ChEMBL_464918 (CHEMBL946975)
IC50
2000±n/a nM
Citation
 Paris, M; Porcelloni, M; Binaschi, M; Fattori, D Histone deacetylase inhibitors: from bench to clinic. J Med Chem 51:1505-29 (2008) [PubMed]  Article 
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM50187086
Synonyms:
(E)-N-(2-aminophenyl)-3-(4-((3,4,5-trimethoxyphenylamino)methyl)phenyl)acrylamide | CHEMBL378942 | N-(2-aminophenyl)-3-(4-((3,4,5-trimethoxyphenylamino)methyl)phenyl)acrylamide
Type:
Small organic molecule
Emp. Form.:
C25H27N3O4
Mol. Mass.:
433.4996
SMILES:
COc1cc(NCc2ccc(\C=C\C(=O)Nc3ccccc3N)cc2)cc(OC)c1OC
Structure:
Search PDB for entries with ligand similarity: