Reaction Details Report a problem with these data
Target
Cytochrome P450 165B3
Ligand
BDBM50373061
Substrate
n/a
Meas. Tech.
ChEMBL_466587 (CHEMBL930237)
Kd
35000±n/a nM
Citation
 Geib, N; Woithe, K; Zerbe, K; Li, DB; Robinson, JA New insights into the first oxidative phenol coupling reaction during vancomycin biosynthesis. Bioorg Med Chem Lett 18:3081-4 (2008) [PubMed]  Article 
Target
Name:
Cytochrome P450 165B3
Synonyms:
C5B3_AMYOR | Vancomycin biosynthesis protein OxyB | cyp165B3 | oxyB
Type:
PROTEIN
Mol. Mass.:
44362.20
Organism:
Amycolatopsis orientalis
Description:
ChEMBL_466587
Residue:
398
Sequence:
MSEDDPRPLHIRRQGLDPADELLAAGALTRVTIGSGADAETHWMATAHAVVRQVMGDHQQFSTRRRWDPRDEIGGKGIFRPRELVGNLMDYDPPEHTRLRRKLTPGFTLRKMQRMAPYIEQIVNDRLDEMERAGSPADLIAFVADKVPGAVLCELVGVPRDDRDMFMKLCHGHLDASLSQKRRAALGDKFSRYLLAMIARERKEPGEGMIGAVVAEYGDDATDEELRGFCVQVMLAGDDNISGMIGLGVLAMLRHPEQIDAFRGDEQSAQRAVDELIRYLTVPYSPTPRIAREDLTLAGQEIKKGDSVICSLPAANRDPALAPDVDRLDVTREPIPHVAFGHGVHHCLGAALARLELRTVFTELWRRFPALRLADPAQDTEFRLTTPAYGLTELMVAW
  
Inhibitor
Name:
BDBM50373061
Synonyms:
CHEMBL258179
Type:
Small organic molecule
Emp. Form.:
C45H53N7O12
Mol. Mass.:
883.942
SMILES:
CN[C@H](CC(C)C)C(=O)N[C@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(=O)N[C@@H](C(=O)N[C@H](Cc1ccc(O)cc1)C(O)=O)c1ccc(O)cc1)c1ccc(O)cc1
Structure:
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