Reaction Details Report a problem with these data
Target
Quorum-sensing transcriptional repressor QscR
Ligand
BDBM50351510
Substrate
n/a
Meas. Tech.
ChEMBL_466841 (CHEMBL925889)
EC50
78±n/a nM
Citation
 Mattmann, ME; Geske, GD; Worzalla, GA; Chandler, JR; Sappington, KJ; Greenberg, EP; Blackwell, HE Synthetic ligands that activate and inhibit a quorum-sensing regulator in Pseudomonas aeruginosa. Bioorg Med Chem Lett 18:3072-5 (2008) [PubMed]  Article 
Target
Name:
Quorum-sensing transcriptional repressor QscR
Synonyms:
PhzR
Type:
PROTEIN
Mol. Mass.:
27251.33
Organism:
Pseudomonas aeruginosa
Description:
ChEMBL_466843
Residue:
237
Sequence:
MHDEREGYLEILSRITTEEEFFSLVLEICGNYGFEFFSFGARAPFPLTAPKYHFLSNYPGEWKSRYISEDYTSIDPIVRHGLLEYTPLIWNGEDFQENRFFWEEALHHGIRHGWSIPVRGKYGLISMLSLVRSSESIAATEILEKESFLLWITSMLQATFGDLLAPRIVPESNVRLTARETEMLKWTAVGKTYGEIGLILSIDQRTVKFHIVNAMRKLNSSNKAEATMKAYAIGLLN
  
Inhibitor
Name:
BDBM50351510
Synonyms:
CHEMBL8463
Type:
Small organic molecule
Emp. Form.:
C18H31NO4
Mol. Mass.:
325.443
SMILES:
CCCCCCCCCCCC(=O)CC(=O)N[C@H]1CCOC1=O
Structure:
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