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Target
2-5A-dependent ribonuclease
Ligand
BDBM50373176
Substrate
n/a
Meas. Tech.
ChEMBL_467044 (CHEMBL929125)
Kd
12000±n/a nM
Citation
 Thakur, CS; Jha, BK; Dong, B; Das Gupta, J; Silverman, KM; Mao, H; Sawai, H; Nakamura, AO; Banerjee, AK; Gudkov, A; Silverman, RH Small-molecule activators of RNase L with broad-spectrum antiviral activity. Proc Natl Acad Sci U S A 104:9585-90 (2007) [PubMed]  Article 
Target
Name:
2-5A-dependent ribonuclease
Synonyms:
2-5A-dependent RNase | 2-5A-dependent ribonuclease | RN5A_HUMAN | RNASEL | RNS4 | RNase L | Ribonuclease 4 | Ribonuclease L
Type:
PROTEIN
Mol. Mass.:
83534.35
Organism:
Homo sapiens (Human)
Description:
ChEMBL_164152
Residue:
741
Sequence:
MESRDHNNPQEGPTSSSGRRAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDCGDLVMTARRNYDHSLVKVLLSHGAKEDFHPPAEDWKPQSSHWGAALKDLHRIYRPMIGKLKFFIDEKYKIADTSEGGIYLGFYEKQEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQEVKRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVGNESDIKTRKSESEILRLLQPGPSEHSKSFDKWTTKINECVMKKMNKFYEKRGNFYQNTVGDLLKFIRNLGEHIDEEKHKKMKLKIGDPSLYFQKTFPDLVIYVYTKLQNTEYRKHFPQTHSPNKPQCDGAGGASGLASPGC
  
Inhibitor
Name:
BDBM50373176
Synonyms:
C-5950331 | CHEMBL259633
Type:
Small organic molecule
Emp. Form.:
C16H14N2O2S
Mol. Mass.:
298.36
SMILES:
Oc1cccc(c1)-c1nc2sc3CCCCc3c2c(=O)[nH]1
Structure:
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