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Target
Glucose-6-phosphate 1-dehydrogenase
Ligand
BDBM50373221
Substrate
n/a
Meas. Tech.
ChEMBL_467395 (CHEMBL921928)
IC50
21760±n/a nM
Citation
 Shin, ES; Park, J; Shin, JM; Cho, D; Cho, SY; Shin, DW; Ham, M; Kim, JB; Lee, TR Catechin gallates are NADP+-competitive inhibitors of glucose-6-phosphate dehydrogenase and other enzymes that employ NADP+ as a coenzyme. Bioorg Med Chem 16:3580-6 (2008) [PubMed]  Article 
Target
Name:
Glucose-6-phosphate 1-dehydrogenase
Synonyms:
G6PD | G6PD_YEAST | MET19 | ZWF1
Type:
PROTEIN
Mol. Mass.:
57518.83
Organism:
Saccharomyces cerevisiae S288c
Description:
ChEMBL_467395
Residue:
505
Sequence:
MSEGPVKFEKNTVISVFGASGDLAKKKTFPALFGLFREGYLDPSTKIFGYARSKLSMEEDLKSRVLPHLKKPHGEADDSKVEQFFKMVSYISGNYDTDEGFDELRTQIEKFEKSANVDVPHRLFYLALPPSVFLTVAKQIKSRVYAENGITRVIVEKPFGHDLASARELQKNLGPLFKEEELYRIDHYLGKELVKNLLVLRFGNQFLNASWNRDNIQSVQISFKERFGTEGRGGYFDSIGIIRDVMQNHLLQIMTLLTMERPVSFDPESIRDEKVKVLKAVAPIDTDDVLLGQYGKSEDGSKPAYVDDDTVDKDSKCVTFAAMTFNIENERWEGVPIMMRAGKALNESKVEIRLQYKAVASGVFKDIPNNELVIRVQPDAAVYLKFNAKTPGLSNATQVTDLNLTYASRYQDFWIPEAYEVLIRDALLGDHSNFVRDDELDISWGIFTPLLKHIERPDGPTPEIYPYGSRGPKGLKEYMQKHKYVMPEKHPYAWPVTKPEDTKDN
  
Inhibitor
Name:
BDBM50373221
Synonyms:
CHEMBL408233
Type:
Small organic molecule
Emp. Form.:
C19H18N4O3
Mol. Mass.:
350.3712
SMILES:
CCOc1cccc(c1)-c1cc([nH]n1)C(=O)NN=Cc1ccccc1O |w:17.18|
Structure:
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