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Target
5-hydroxytryptamine receptor 2A
Ligand
BDBM50373715
Substrate
n/a
Meas. Tech.
ChEMBL_468369 (CHEMBL931953)
Ki
5400±n/a nM
Citation
 Tietze, R; Löber, S; Hübner, H; Gmeiner, P; Kuwert, T; Prante, O Discovery of a dopamine D4 selective PET ligand candidate taking advantage of a click chemistry based REM linker. Bioorg Med Chem Lett 18:983-8 (2008) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 2A
Synonyms:
5-HT-2 | 5-HT-2A | 5-HT2 | 5-HT2A | 5HT2A_PIG | HTR2A | Serotonin 2a (5-HT2a) receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
52679.13
Organism:
PIG
Description:
5-HT2 0 0::P50129
Residue:
470
Sequence:
MDVLCEENTSLSSPTNSFMQLNDDTRLYHNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPPCFSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHRRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQTGQKENSKQDDKATENDCTMVALGKQHSEDAPADNSNTVNEKVSCV
  
Inhibitor
Name:
BDBM50373715
Synonyms:
CHEMBL271513
Type:
Small organic molecule
Emp. Form.:
C20H25FN2O2
Mol. Mass.:
344.4231
SMILES:
COc1ccccc1N1CCN(Cc2ccc(OCCF)cc2)CC1
Structure:
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