Reaction Details Report a problem with these data
Target
Orexin receptor type 2
Ligand
BDBM50374442
Substrate
n/a
Meas. Tech.
ChEMBL_469337 (CHEMBL932891)
Ki
0.1±n/a nM
Citation
 Bergman, JM; Roecker, AJ; Mercer, SP; Bednar, RA; Reiss, DR; Ransom, RW; Meacham Harrell, C; Pettibone, DJ; Lemaire, W; Murphy, KL; Li, C; Prueksaritanont, T; Winrow, CJ; Renger, JJ; Koblan, KS; Hartman, GD; Coleman, PJ Proline bis-amides as potent dual orexin receptor antagonists. Bioorg Med Chem Lett 18:1425-30 (2008) [PubMed]  Article 
Target
Name:
Orexin receptor type 2
Synonyms:
HCRTR2 | Hypocretin receptor type 2 | OX2R_HUMAN | Orexin receptor type 2 (OR 2) | Orexin receptor type 2 (OR-2) | Orexin receptor type 2 (OX2) | Orexin receptor type 2 (OX2R) | Orexin receptor type 2 (OxR2) | Ox-2-R | Ox2-R
Type:
Protein
Mol. Mass.:
50710.53
Organism:
Homo sapiens (Human)
Description:
O43614
Residue:
444
Sequence:
MSGTKLEDSPPCRNWSSASELNETQEPFLNPTDYDDEEFLRYLWREYLHPKEYEWVLIAGYIIVFVVALIGNVLVCVAVWKNHHMRTVTNYFIVNLSLADVLVTITCLPATLVVDITETWFFGQSLCKVIPYLQTVSVSVSVLTLSCIALDRWYAICHPLMFKSTAKRARNSIVIIWIVSCIIMIPQAIVMECSTVFPGLANKTTLFTVCDERWGGEIYPKMYHICFFLVTYMAPLCLMVLAYLQIFRKLWCRQIPGTSSVVQRKWKPLQPVSQPRGPGQPTKSRMSAVAAEIKQIRARRKTARMLMIVLLVFAICYLPISILNVLKRVFGMFAHTEDRETVYAWFTFSHWLVYANSAANPIIYNFLSGKFREEFKAAFSCCCLGVHHRQEDRLTRGRTSTESRKSLTTQISNFDNISKLSEQVVLTSISTLPAANGAGPLQNW
  
Inhibitor
Name:
BDBM50374442
Synonyms:
CHEMBL255763
Type:
Small organic molecule
Emp. Form.:
C26H27N5O2S
Mol. Mass.:
473.59
SMILES:
Cc1ccc2nc(SCC(=O)N3CCC[C@H]3C(=O)Nc3ccccc3-n3cccc3)n(C)c2c1
Structure:
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