Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50145022
Substrate
n/a
Meas. Tech.
ChEMBL_469411 (CHEMBL933018)
Ki
6.5±n/a nM
Citation
 Colabufo, NA; Abate, C; Contino, M; Inglese, C; Niso, M; Berardi, F; Perrone, R PB183, a sigma receptor ligand, as a potential PET probe for the imaging of prostate adenocarcinoma. Bioorg Med Chem Lett 18:1990-3 (2008) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Opioid receptor, sigma 1 | Oprs1 | SGMR1_MOUSE | Sigma 1-type opioid receptor | Sigma1-receptor | Sigma1R | Sigmar1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25246.51
Organism:
Mus musculus (Mouse)
Description:
O55242
Residue:
223
Sequence:
MPWAAGRRWAWITLILTIIAVLIQAAWLWLGTQNFVFSREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCILHASLSEYVLLFGTALGSHGHSGRYWAEISDTIISGTFHQWKEGTTKSEVFYPGETVVHGPGEATALEWGPNTWMVEYGRGVIPSTLFFALADTFFSTQDYLTLFYTLRAYARGLRLELTTYLFGQDS
  
Inhibitor
Name:
BDBM50145022
Synonyms:
1-Cyclohexyl-4-[3-(5-methoxy-naphthalen-1-yl)-propyl]-piperazine | 1-cyclohexyl-4-(3-(5-methoxynaphthalen-1-yl)propyl)piperazine | CHEMBL535856 | CHEMBL75286 | PB-183
Type:
Small organic molecule
Emp. Form.:
C24H34N2O
Mol. Mass.:
366.5396
SMILES:
COc1cccc2c(CCCN3CCN(CC3)C3CCCCC3)cccc12
Structure:
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