Reaction Details Report a problem with these data
Target
Casein kinase II subunit alpha
Ligand
BDBM50374663
Substrate
n/a
Meas. Tech.
ChEMBL_469783 (CHEMBL947049)
Ki
24±n/a nM
Citation
 Nie, Z; Perretta, C; Erickson, P; Margosiak, S; Lu, J; Averill, A; Almassy, R; Chu, S Structure-based design and synthesis of novel macrocyclic pyrazolo[1,5-a] [1,3,5]triazine compounds as potent inhibitors of protein kinase CK2 and their anticancer activities. Bioorg Med Chem Lett 18:619-23 (2008) [PubMed]  Article 
Target
Name:
Casein kinase II subunit alpha
Synonyms:
ACK2 | CK II | CK2- alpha | CSK2A_MAIZE | Casein Kinase II
Type:
Enzyme
Mol. Mass.:
39238.74
Organism:
Zea mays (Maize)
Description:
n/a
Residue:
332
Sequence:
MSKARVYADVNVLRPKEYWDYEALTVQWGEQDDYEVVRKVGRGKYSEVFEGINVNNNEKCIIKILKPVKKKKIKREIKILQNLCGGPNIVKLLDIVRDQHSKTPSLIFEYVNNTDFKVLYPTLTDYDIRYYIYELLKALDYCHSQGIMHRDVKPHNVMIDHELRKLRLIDWGLAEFYHPGKEYNVRVASRYFKGPELLVDLQDYDYSLDMWSLGCMFAGMIFRKEPFFYGHDNHDQLVKIAKVLGTDGLNVYLNKYRIELDPQLEALVGRHSRKPWLKFMNADNQHLVSPEAIDFLDKLLRYDHQERLTALEAMTHPYFQQVRAAENSRTRA
  
Inhibitor
Name:
BDBM50374663
Synonyms:
CHEMBL404508
Type:
Small organic molecule
Emp. Form.:
C19H21N7O
Mol. Mass.:
363.4163
SMILES:
O=C1CCCCc2cnn3c(NC4CC4)nc(Nc4cccc(N1)c4)nc23
Structure:
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