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Target
Farnesyl diphosphate synthase
Ligand
BDBM50374763
Substrate
n/a
Meas. Tech.
ChEMBL_469917 (CHEMBL939264)
IC50
1210±n/a nM
Citation
 Szajnman, SH; García Liñares, GE; Li, ZH; Jiang, C; Galizzi, M; Bontempi, EJ; Ferella, M; Moreno, SN; Docampo, R; Rodriguez, JB Synthesis and biological evaluation of 2-alkylaminoethyl-1,1-bisphosphonic acids against Trypanosoma cruzi and Toxoplasma gondii targeting farnesyl diphosphate synthase. Bioorg Med Chem 16:3283-90 (2008) [PubMed]  Article 
Target
Name:
Farnesyl diphosphate synthase
Synonyms:
n/a
Type:
PROTEIN
Mol. Mass.:
48827.21
Organism:
Trypanosoma cruzi
Description:
ChEMBL_939177
Residue:
425
Sequence:
MTAFACFPHSLFYSTRLPFFFFFFCVCVHCCLRYLCLLKCAYCCSDKNYFRPLNYFFYCLYLAMASMERFLSVYDEVQAFLLDQLQSKYEIDPNRARYLRIMMDTTCLGGKYFRGMTVVNVAEGFLAVTQHDEATKERILHDACVGGWMIEFLQAHYLVEDDIMDGSVMRRGKPCWYRFPGVTTQCAINDGIILKSWTQIMAWHYFADRPFLKDLLCLFQKVDYATAVGQMYDVTSMCDSNKLDPEVAQPMTTDFAEFTPAIYKRIVKYKTTFYTYLLPLVMGLLVSEAAASVEMNLVERVAHLIGEYFQVQDDVMDCFTPPEQLGKVGTDIEDAKCSWLAVTFLGKANAAQVAEFKANYGEKDPAKVAVVKRLYSKANLQADFAAYEAEVVREVESLIEQLKVKSPTFAESVAVVWEKTHKRKK
  
Inhibitor
Name:
BDBM50374763
Synonyms:
CHEMBL405827
Type:
Small organic molecule
Emp. Form.:
C6H17NO6P2
Mol. Mass.:
261.1498
SMILES:
CC(C)(C)NCC(P(O)(O)=O)P(O)(O)=O
Structure:
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