Reaction Details Report a problem with these data
Target
Coagulation factor X
Ligand
BDBM50374881
Substrate
n/a
Meas. Tech.
ChEMBL_470061 (CHEMBL933439)
Ki
1.7±n/a nM
Citation
 Smallheer, JM; Wang, S; Laws, ML; Nakajima, S; Hu, Z; Han, W; Jacobson, I; Luettgen, JM; Rossi, KA; Rendina, AR; Knabb, RM; Wexler, RR; Lam, PY; Quan, ML Sulfonamidolactam inhibitors of coagulation factor Xa. Bioorg Med Chem Lett 18:2428-33 (2008) [PubMed]  Article 
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
  
Inhibitor
Name:
BDBM50374881
Synonyms:
CHEMBL270565
Type:
Small organic molecule
Emp. Form.:
C33H39ClFN5O5S
Mol. Mass.:
672.21
SMILES:
CN(C)CCN(C)C(=O)CN(C1CCCN(C1=O)c1ccc(cc1F)N1CCCCC1=O)S(=O)(=O)c1ccc2cc(Cl)ccc2c1 |w:11.10|
Structure:
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