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Target
Potassium voltage-gated channel subfamily A member 4
Ligand
BDBM50375409
Substrate
n/a
Meas. Tech.
ChEMBL_471773 (CHEMBL939978)
EC50
2300±n/a nM
Citation
 Lu, Q; Peevey, J; Jow, F; Monaghan, MM; Mendoza, G; Zhang, H; Wu, J; Kim, CY; Bicksler, J; Greenblatt, L; Lin, SS; Childers, W; Bowlby, MR Disruption of Kv1.1 N-type inactivation by novel small molecule inhibitors (disinactivators). Bioorg Med Chem 16:3067-75 (2008) [PubMed]  Article 
Target
Name:
Potassium voltage-gated channel subfamily A member 4
Synonyms:
KCNA4 | KCNA4L | KCNA4_HUMAN | Voltage-gated potassium channel | Voltage-gated potassium channel subunit Kv1.4
Type:
PROTEIN
Mol. Mass.:
73234.81
Organism:
Homo sapiens (Human)
Description:
ChEMBL_471773
Residue:
653
Sequence:
MEVAMVSAESSGCNSHMPYGYAAQARARERERLAHSRAAAAAAVAAATAAVEGSGGSGGGSHHHHQSRGACTSHDPQSSRGSRRRRRQRSEKKKAHYRQSSFPHCSDLMPSGSEEKILRELSEEEEDEEEEEEEEEEGRFYYSEDDHGDECSYTDLLPQDEGGGGYSSVRYSDCCERVVINVSGLRFETQMKTLAQFPETLLGDPEKRTQYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLKRPVNVPFDIFTEEVKFYQLGEEALLKFREDEGFVREEEDRALPENEFKKQIWLLFEYPESSSPARGIAIVSVLVILISIVIFCLETLPEFRDDRDLVMALSAGGHGGLLNDTSAPHLENSGHTIFNDPFFIVETVCIVWFSFEFVVRCFACPSQALFFKNIMNIIDIVSILPYFITLGTDLAQQQGGGNGQQQQAMSFAILRIIRLVRVFRIFKLSRHSKGLQILGHTLRASMRELGLLIFFLFIGVILFSSAVYFAEADEPTTHFQSIPDAFWWAVVTMTTVGYGDMKPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEQTQLTQNAVSCPYLPSNLLKKFRSSTSSSLGDKSEYLEMEEGVKESLCAKEEKCQGKGDDSETDKNNCSNAKAVETDV
  
Inhibitor
Name:
BDBM50375409
Synonyms:
CHEMBL408488
Type:
Small organic molecule
Emp. Form.:
C6H10BrNO4
Mol. Mass.:
240.052
SMILES:
CC1(C)OCC(Br)(CO1)[N+]([O-])=O
Structure:
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