Reaction Details
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Potassium voltage-gated channel subfamily A member 4
Ligand
BDBM50375408
Substrate
n/a
Meas. Tech.
ChEMBL_471773 (CHEMBL939978)
EC50
1300±n/a nM
Citation
Lu, Q; Peevey, J; Jow, F; Monaghan, MM; Mendoza, G; Zhang, H; Wu, J; Kim, CY; Bicksler, J; Greenblatt, L; Lin, SS; Childers, W; Bowlby, MR Disruption of Kv1.1 N-type inactivation by novel small molecule inhibitors (disinactivators). Bioorg Med Chem 16:3067-75 (2008) [PubMed] Article More Info.:
Target
Name:
Potassium voltage-gated channel subfamily A member 4
Synonyms:
KCNA4 | KCNA4L | KCNA4_HUMAN | Voltage-gated potassium channel | Voltage-gated potassium channel subunit Kv1.4
Type:
PROTEIN
Mol. Mass.:
73234.81
Organism:
Homo sapiens (Human)
Description:
ChEMBL_471773
Residue:
653
Sequence:
MEVAMVSAESSGCNSHMPYGYAAQARARERERLAHSRAAAAAAVAAATAAVEGSGGSGGGSHHHHQSRGACTSHDPQSSRGSRRRRRQRSEKKKAHYRQSSFPHCSDLMPSGSEEKILRELSEEEEDEEEEEEEEEEGRFYYSEDDHGDECSYTDLLPQDEGGGGYSSVRYSDCCERVVINVSGLRFETQMKTLAQFPETLLGDPEKRTQYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLKRPVNVPFDIFTEEVKFYQLGEEALLKFREDEGFVREEEDRALPENEFKKQIWLLFEYPESSSPARGIAIVSVLVILISIVIFCLETLPEFRDDRDLVMALSAGGHGGLLNDTSAPHLENSGHTIFNDPFFIVETVCIVWFSFEFVVRCFACPSQALFFKNIMNIIDIVSILPYFITLGTDLAQQQGGGNGQQQQAMSFAILRIIRLVRVFRIFKLSRHSKGLQILGHTLRASMRELGLLIFFLFIGVILFSSAVYFAEADEPTTHFQSIPDAFWWAVVTMTTVGYGDMKPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETENEEQTQLTQNAVSCPYLPSNLLKKFRSSTSSSLGDKSEYLEMEEGVKESLCAKEEKCQGKGDDSETDKNNCSNAKAVETDV
Inhibitor
Name:
BDBM50375408
Synonyms:
CHEMBL259345
Type:
Small organic molecule
Emp. Form.:
C10H10BrNO4
Mol. Mass.:
288.095
SMILES:
[O-][N+](=O)C1(Br)COC(OC1)c1ccccc1 |(.89,-23.14,;-.45,-22.38,;-.46,-20.84,;-1.78,-23.16,;-3.12,-22.39,;-.45,-23.94,;-.45,-25.47,;-1.78,-26.24,;-3.11,-25.48,;-3.11,-23.93,;-1.77,-27.77,;-3.1,-28.54,;-3.1,-30.09,;-1.76,-30.86,;-.43,-30.09,;-.43,-28.54,)|
Structure:
