Reaction Details Report a problem with these data
Target
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
Ligand
BDBM50375614
Substrate
n/a
Meas. Tech.
ChEMBL_473188 (CHEMBL921298)
Ki
21.3±n/a nM
Citation
 Sydnes, MO; Kuse, M; Kurono, M; Shimomura, A; Ohinata, H; Takai, A; Isobe, M Protein phosphatase inhibitory activity of tautomycin photoaffinity probes evaluated at femto-molar level. Bioorg Med Chem 16:1747-55 (2008) [PubMed]  Article 
Target
Name:
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
Synonyms:
PP1G_HUMAN | PPP1CC | Serine/threonine protein phosphatase PP1-gamma catalytic subunit
Type:
PROTEIN
Mol. Mass.:
36983.39
Organism:
Homo sapiens (Human)
Description:
ChEMBL_473188
Residue:
323
Sequence:
MADLDKLNIDSIIQRLLEVRGSKPGKNVQLQENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVLGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPAEKKKPNATRPVTPPRGMITKQAKK
  
Inhibitor
Name:
BDBM50375614
Synonyms:
CHEMBL259235
Type:
Small organic molecule
Emp. Form.:
C55H82F3N5O17
Mol. Mass.:
1142.2581
SMILES:
CO[C@@H]([C@H](O)CC(=O)[C@@H](C)[C@@H](O)CC[C@@H](C)[C@@H]1O[C@]2(CC[C@@H](C)[C@H](CC[C@H](C)C(\C)=N\OCC(=O)NCCNC(=O)c3ccc(cc3OC)C3(N=N3)C(F)(F)F)O2)CC[C@@H]1C)[C@H](OC(=O)C[C@@H](O)C(\C(O)=O)=C(/C)C(O)=O)C(C)C |c:51|
Structure:
Search PDB for entries with ligand similarity: