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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50375792
Substrate
n/a
Meas. Tech.
ChEMBL_474267 (CHEMBL935072)
IC50
0.7±n/a nM
Citation
 Chen, MH; Fitzgerald, P; Singh, SB; O'Neill, EA; Schwartz, CD; Thompson, CM; O'Keefe, SJ; Zaller, DM; Doherty, JB Synthesis and biological activity of quinolinone and dihydroquinolinone p38 MAP kinase inhibitors. Bioorg Med Chem Lett 18:2222-6 (2008) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50375792
Synonyms:
CHEMBL257236
Type:
Small organic molecule
Emp. Form.:
C21H12Cl3NO2
Mol. Mass.:
416.684
SMILES:
Oc1cc(-c2ccccc2Cl)c2ccc(=O)n(-c3c(Cl)cccc3Cl)c2c1 |(-.42,-39.44,;-1.76,-40.22,;-1.75,-41.76,;-3.08,-42.53,;-3.08,-44.07,;-4.42,-44.84,;-4.42,-46.38,;-3.09,-47.15,;-1.75,-46.37,;-1.75,-44.83,;-.42,-44.06,;-4.41,-41.76,;-5.74,-42.53,;-7.07,-41.76,;-7.07,-40.22,;-8.41,-39.45,;-5.74,-39.44,;-5.74,-37.9,;-7.06,-37.13,;-8.4,-37.9,;-7.07,-35.59,;-5.73,-34.82,;-4.39,-35.59,;-4.39,-37.13,;-3.06,-37.9,;-4.41,-40.22,;-3.09,-39.45,)|
Structure:
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