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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50375788
Substrate
n/a
Meas. Tech.
ChEMBL_474267 (CHEMBL935072)
IC50
0.5±n/a nM
Citation
 Chen, MH; Fitzgerald, P; Singh, SB; O'Neill, EA; Schwartz, CD; Thompson, CM; O'Keefe, SJ; Zaller, DM; Doherty, JB Synthesis and biological activity of quinolinone and dihydroquinolinone p38 MAP kinase inhibitors. Bioorg Med Chem Lett 18:2222-6 (2008) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50375788
Synonyms:
CHEMBL257697
Type:
Small organic molecule
Emp. Form.:
C26H22Cl3N3O4
Mol. Mass.:
546.83
SMILES:
NC(CO)C(=O)NCCOc1cc(-c2ccccc2Cl)c2ccc(=O)n(-c3c(Cl)cccc3Cl)c2c1 |w:1.0,(30.03,-41.17,;28.7,-41.95,;28.71,-43.49,;30.05,-44.25,;27.36,-41.18,;26.03,-41.96,;27.35,-39.63,;26.01,-38.88,;24.67,-39.65,;23.34,-38.88,;22,-39.66,;22.01,-41.2,;20.68,-41.97,;20.68,-43.51,;19.34,-44.28,;19.34,-45.82,;20.67,-46.59,;22.01,-45.81,;22.01,-44.28,;23.34,-43.5,;19.35,-41.2,;18.02,-41.97,;16.69,-41.21,;16.69,-39.66,;15.35,-38.9,;18.02,-38.89,;18.02,-37.34,;16.7,-36.58,;15.36,-37.35,;16.69,-35.04,;18.03,-34.26,;19.37,-35.03,;19.37,-36.57,;20.7,-37.34,;19.35,-39.66,;20.68,-38.9,)|
Structure:
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