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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50375805
Substrate
n/a
Meas. Tech.
ChEMBL_474267 (CHEMBL935072)
IC50
1.5±n/a nM
Citation
 Chen, MH; Fitzgerald, P; Singh, SB; O'Neill, EA; Schwartz, CD; Thompson, CM; O'Keefe, SJ; Zaller, DM; Doherty, JB Synthesis and biological activity of quinolinone and dihydroquinolinone p38 MAP kinase inhibitors. Bioorg Med Chem Lett 18:2222-6 (2008) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50375805
Synonyms:
CHEMBL403925
Type:
Small organic molecule
Emp. Form.:
C22H14Cl3NO2
Mol. Mass.:
430.711
SMILES:
COc1cc(-c2ccccc2Cl)c2ccc(=O)n(-c3c(Cl)cccc3Cl)c2c1 |(13.91,-23.23,;13.92,-24.77,;12.59,-25.55,;12.59,-27.09,;11.26,-27.86,;11.26,-29.4,;9.92,-30.17,;9.92,-31.71,;11.25,-32.48,;12.59,-31.7,;12.59,-30.16,;13.92,-29.39,;9.93,-27.09,;8.6,-27.86,;7.27,-27.09,;7.27,-25.55,;5.93,-24.78,;8.6,-24.77,;8.6,-23.23,;7.28,-22.46,;5.94,-23.24,;7.27,-20.93,;8.61,-20.15,;9.95,-20.92,;9.95,-22.46,;11.28,-23.23,;9.93,-25.55,;11.26,-24.78,)|
Structure:
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