Reaction Details Report a problem with these data
Target
DNA polymerase beta
Ligand
BDBM50376364
Substrate
n/a
Meas. Tech.
ChEMBL_476057 (CHEMBL921745)
IC50
>250000±n/a nM
Citation
 Gao, Z; Maloney, DJ; Dedkova, LM; Hecht, SM Inhibitors of DNA polymerase beta: activity and mechanism. Bioorg Med Chem 16:4331-40 (2008) [PubMed]  Article 
Target
Name:
DNA polymerase beta
Synonyms:
DNA polymerase beta (Pol β) | DPOLB_HUMAN | POLB
Type:
Protein
Mol. Mass.:
38188.76
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
335
Sequence:
MSKRKAPQETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIKTLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGSFRRGAESSGDMDVLLTHPSFTSESTKQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQLPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE
  
Inhibitor
Name:
BDBM50376364
Synonyms:
STIGMASTEROL
Type:
Small organic molecule
Emp. Form.:
C29H48O
Mol. Mass.:
412.6908
SMILES:
CC[C@H](\C=C\[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C)C(C)C |r,t:13|
Structure:
Search PDB for entries with ligand similarity: