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Target
DNA polymerase beta
Ligand
BDBM50237597
Substrate
n/a
Meas. Tech.
ChEMBL_476057 (CHEMBL921745)
IC50
31430±n/a nM
Citation
 Gao, Z; Maloney, DJ; Dedkova, LM; Hecht, SM Inhibitors of DNA polymerase beta: activity and mechanism. Bioorg Med Chem 16:4331-40 (2008) [PubMed]  Article 
Target
Name:
DNA polymerase beta
Synonyms:
DNA polymerase beta (Pol β) | DPOLB_HUMAN | POLB
Type:
Protein
Mol. Mass.:
38188.76
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
335
Sequence:
MSKRKAPQETLNGGITDMLTELANFEKNVSQAIHKYNAYRKAASVIAKYPHKIKSGAEAKKLPGVGTKIAEKIDEFLATGKLRKLEKIRQDDTSSSINFLTRVSGIGPSAARKFVDEGIKTLEDLRKNEDKLNHHQRIGLKYFGDFEKRIPREEMLQMQDIVLNEVKKVDSEYIATVCGSFRRGAESSGDMDVLLTHPSFTSESTKQPKLLHQVVEQLQKVHFITDTLSKGETKFMGVCQLPSKNDEKEYPHRRIDIRLIPKDQYYCGVLYFTGSDIFNKNMRAHALEKGFTINEYTIRPLGVTGVAGEPLPVDSEKDIFDYIQWKYREPKDRSE
  
Inhibitor
Name:
BDBM50237597
Synonyms:
7-hydroxy-3,7'-dicoumaryl ether | 7-hydroxy-3-(2-oxo-2H-chromen-7-yloxy)chromen-2-one | CHEMBL259025
Type:
Small organic molecule
Emp. Form.:
C18H10O6
Mol. Mass.:
322.2684
SMILES:
Oc1ccc2cc(Oc3ccc4ccc(=O)oc4c3)c(=O)oc2c1
Structure:
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