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Target
Potassium voltage-gated channel subfamily A member 5
Ligand
BDBM50211535
Substrate
n/a
Meas. Tech.
ChEMBL_477686 (CHEMBL937483)
IC50
60±n/a nM
Citation
 Finlay, HJ; Lloyd, J; Nyman, M; Conder, ML; West, T; Levesque, P; Atwal, K Pyrano-[2,3b]-pyridines as potassium channel antagonists. Bioorg Med Chem Lett 18:2714-8 (2008) [PubMed]  Article 
Target
Name:
Potassium voltage-gated channel subfamily A member 5
Synonyms:
HK2 | HPCN1 | KCNA5 | KCNA5_HUMAN | Potassium voltage-gated channel subfamily A member 5 | Voltage-gated potassium channel | Voltage-gated potassium channel subunit Kv1.5
Type:
Enzyme
Mol. Mass.:
67222.47
Organism:
Homo sapiens (Human)
Description:
P22460
Residue:
613
Sequence:
MEIALVPLENGGAMTVRGGDEARAGCGQATGGELQCPPTAGLSDGPKEPAPKGRGAQRDADSGVRPLPPLPDPGVRPLPPLPEELPRPRRPPPEDEEEEGDPGLGTVEDQALGTASLHHQRVHINISGLRFETQLGTLAQFPNTLLGDPAKRLRYFDPLRNEYFFDRNRPSFDGILYYYQSGGRLRRPVNVSLDVFADEIRFYQLGDEAMERFREDEGFIKEEEKPLPRNEFQRQVWLIFEYPESSGSARAIAIVSVLVILISIITFCLETLPEFRDERELLRHPPAPHQPPAPAPGANGSGVMAPPSGPTVAPLLPRTLADPFFIVETTCVIWFTFELLVRFFACPSKAGFSRNIMNIIDVVAIFPYFITLGTELAEQQPGGGGGGQNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGKTLQASMRELGLLIFFLFIGVILFSSAVYFAEADNQGTHFSSIPDAFWWAVVTMTTVGYGDMRPITVGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETDHEEPAVLKEEQGTQSQGPGLDRGVQRKVSGSRGSFCKAGGTLENADSARRGSCPLEKCNVKAKSNVDLRRSLYALCLDTSRETDL
  
Inhibitor
Name:
BDBM50211535
Synonyms:
CHEMBL387993 | N-((3S,4R)-6-((S)-2-((2,6-dimethylphenylamino)methyl)pyrrolidine-1-carbonyl)-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-chromen-4-yl)-4-ethylbenzenesulfonamide | rac-trans-N-(6-((S)-2-((2,6-dimethylphenylamino)methyl)pyrrolidine-1-carbonyl)-3-hydroxy-2,2-dimethyl-3,4-dihydro-2H-chromen-4-yl)-4-ethylbenzenesulfonamide
Type:
Small organic molecule
Emp. Form.:
C33H41N3O5S
Mol. Mass.:
591.761
SMILES:
CCc1ccc(cc1)S(=O)(=O)N[C@H]1[C@H](O)C(C)(C)Oc2ccc(cc12)C(=O)N1CCC[C@H]1CNc1c(C)cccc1C
Structure:
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