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Target
Phospholipase A2
Ligand
BDBM50259941
Substrate
n/a
Meas. Tech.
ChEMBL_548735 (CHEMBL1024188)
IC50
600±n/a nM
Citation
 Randazzo, A; Debitus, C; Minale, L; García Pastor, P; Alcaraz, MJ; Payá, M; Gomez-Paloma, L Petrosaspongiolides M-R: new potent and selective phospholipase A2 inhibitors from the New Caledonian marine sponge Petrosaspongia nigra. J Nat Prod 61:571-5 (1998) [PubMed]  Article 
Target
Name:
Phospholipase A2
Synonyms:
Allergen Api m I | Allergen=Api m 1 | PA2_APIME | Phosphatidylcholine 2-acylhydrolase | Phospholipase A2 (Bee)
Type:
PROTEIN
Mol. Mass.:
19061.47
Organism:
Apis mellifera
Description:
ChEMBL_1277435
Residue:
167
Sequence:
MQVVLGSLFLLLLSTSHGWQIRDRIGDNELEERIIYPGTLWCGHGNKSSGPNELGRFKHTDACCRTHDMCPDVMSAGESKHGLTNTASHTRLSCDCDDKFYDCLKNSADTISSYFVGKMYFNLIDTKCYKLEHPVTGCGERTEGRCLHYTVDKSKPKVYQWFDLRKY
  
Inhibitor
Name:
BDBM50259941
Synonyms:
CHEMBL470339 | Petrosaspongiolide M
Type:
Small organic molecule
Emp. Form.:
C27H40O6
Mol. Mass.:
460.6029
SMILES:
CC(=O)O[C@@H]1O[C@H](C[C@@H]2[C@@H]1CC[C@H]1[C@@]2(C)CC[C@H]2C(C)(C)CCC[C@]12C)C1=CC(=O)OC1O |r,t:30|
Structure:
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