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Target
Prostaglandin G/H synthase 1
Ligand
BDBM50339185
Substrate
n/a
Meas. Tech.
ChEMBL_550432 (CHEMBL1003454)
IC50
11000±n/a nM
Citation
 Ringbom, T; Segura, L; Noreen, Y; Perera, P; Bohlin, L Ursolic acid from Plantago major, a selective inhibitor of cyclooxygenase-2 catalyzed prostaglandin biosynthesis. J Nat Prod 61:1212-5 (1998) [PubMed]  Article 
Target
Name:
Prostaglandin G/H synthase 1
Synonyms:
COX-1 | Cyclooxygenase | Cyclooxygenase-1 | Cyclooxygenase-1 (COX-1) | Prostaglandin G/H synthase (cyclooxygenase) | PGH1_HUMAN | PTGS1 | COX1
Type:
Enzyme
Mol. Mass.:
68692.62
Organism:
Human
Description:
P23219
Residue:
599
Sequence:
MSRSLLLWFLLFLLLLPPLPVLLADPGAPTPVNPCCYYPCQHQGICVRFGLDRYQCDCTRTGYSGPNCTIPGLWTWLRNSLRPSPSFTHFLLTHGRWFWEFVNATFIREMLMRLVLTVRSNLIPSPPTYNSAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDAQLLARRFLLRRKFIPDPQGTNLMFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDNLERQYQLRLFKDGKLKYQVLDGEMYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFGLLPGLMLYATLWLREHNRVCDLLKAEHPTWGDEQLFQTTRLILIGETIKIVIEEYVQQLSGYFLQLKFDPELLFGVQFQYRNRIAMEFNHLYHWHPLMPDSFKVGSQEYSYEQFLFNTSMLVDYGVEALVDAFSRQIAGRIGGGRNMDHHILHVAVDVIRESREMRLQPFNEYRKRFGMKPYTSFQELVGEKEMAAELEELYGDIDALEFYPGLLLEKCHPNSIFGESMIEIGAPFSLKGLLGNPICSPEYWKPSTFGGEVGFNIVKTATLKKLVCLNTKTCPYVSFRVPDASQDDGPAVERPSTEL
  
Inhibitor
Name:
BDBM50339185
Synonyms:
(2S)-2-(6-methoxynaphthalen-2-yl)propanoic acid | (S)-2-(6-Methoxy-naphthalen-2-yl)-propionic acid | (S)-2-(6-methoxynaphthalen-2-yl)propanoic acid | (S)-naproxen | 2-(6-Methoxy-naphthalen-2-yl)-propionic acid | 2-(6-Methoxy-naphthalen-2-yl)-propionic acid(naproxen) | 2-(6-methoxy-2-naphthyl)propanoic acid | 2-(6-methoxynaphthalen-2-yl)propanoic acid | Aleve | Anaprox | Ec-naprosyn | Equiproxen | Naprelan | Naprosyn | Naproxen2-(6-Methoxy-naphthalen-2-yl)-propionic acid | RS-3540 | CHEMBL154 | naproxene | S-NAPROXEN | Naproxen | US11459295, Compound S-Naproxen (1)
Type:
Small organic molecule
Emp. Form.:
C14H14O3
Mol. Mass.:
n/a
SMILES:
C[C@@H](c1ccc2cc(ccc2c1)OC)C(=O)O
Structure:
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