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Target
Histamine H4 receptor
Ligand
BDBM22913
Substrate
n/a
Meas. Tech.
ChEMBL_552365 (CHEMBL1005955)
Ki
7.8±n/a nM
Citation
 Kiss, R; Kiss, B; Könczöl, A; Szalai, F; Jelinek, I; László, V; Noszál, B; Falus, A; Keseru, GM Discovery of novel human histamine H4 receptor ligands by large-scale structure-based virtual screening. J Med Chem 51:3145-53 (2008) [PubMed]  Article 
Target
Name:
Histamine H4 receptor
Synonyms:
AXOR35 | G-protein coupled receptor 105 | GPCR105 | GPRv53 | HH4R | HISTAMINE H4 | HRH4 | HRH4_HUMAN | Histamine H4 receptor | Histamine H4 receptor (H4R) | Histamine receptor (H3 and H4) | Pfi-013 | SP9144
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44517.02
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH4R receptors.
Residue:
390
Sequence:
MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
  
Inhibitor
Name:
BDBM22913
Synonyms:
CHEMBL1237146 | CHEMBL498770 | Iodophenpropit | {[3-(1H-imidazol-5-yl)propyl]sulfanyl}-N''-[2-(4-iodophenyl)ethyl]methanimidamide
Type:
Small organic molecule
Emp. Form.:
C15H19IN4S
Mol. Mass.:
414.308
SMILES:
NC(SCCCc1cnc[nH]1)=NCCc1ccc(I)cc1 |w:11.12|
Structure:
Search PDB for entries with ligand similarity: