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Target
Histamine H4 receptor
Ligand
BDBM50261081
Substrate
n/a
Meas. Tech.
ChEMBL_552365 (CHEMBL1005955)
Ki
219±n/a nM
Citation
 Kiss, R; Kiss, B; Könczöl, A; Szalai, F; Jelinek, I; László, V; Noszál, B; Falus, A; Keseru, GM Discovery of novel human histamine H4 receptor ligands by large-scale structure-based virtual screening. J Med Chem 51:3145-53 (2008) [PubMed]  Article 
Target
Name:
Histamine H4 receptor
Synonyms:
AXOR35 | G-protein coupled receptor 105 | GPCR105 | GPRv53 | HH4R | HISTAMINE H4 | HRH4 | HRH4_HUMAN | Histamine H4 receptor | Histamine H4 receptor (H4R) | Histamine receptor (H3 and H4) | Pfi-013 | SP9144
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44517.02
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH4R receptors.
Residue:
390
Sequence:
MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
  
Inhibitor
Name:
BDBM50261081
Synonyms:
[amino({2-[(1Z)-4-{[4-(ethoxycarbonyl)phenyl]amino}-2-oxo-1,2-dihydronaphthalen-1-ylidene]hydrazin-1-yl})methylidene]azanium
Type:
Small organic molecule
Emp. Form.:
C20H20N5O3
Mol. Mass.:
378.404
SMILES:
CCOC(=O)c1ccc(Nc2cc(O)c(N=[NH+]C(N)=N)c3ccccc23)cc1 |w:15.14|
Structure:
Search PDB for entries with ligand similarity: