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Target
Histamine H4 receptor
Ligand
BDBM50261036
Substrate
n/a
Meas. Tech.
ChEMBL_552365 (CHEMBL1005955)
Ki
1480±n/a nM
Citation
 Kiss, R; Kiss, B; Könczöl, A; Szalai, F; Jelinek, I; László, V; Noszál, B; Falus, A; Keseru, GM Discovery of novel human histamine H4 receptor ligands by large-scale structure-based virtual screening. J Med Chem 51:3145-53 (2008) [PubMed]  Article 
Target
Name:
Histamine H4 receptor
Synonyms:
AXOR35 | G-protein coupled receptor 105 | GPCR105 | GPRv53 | HH4R | HISTAMINE H4 | HRH4 | HRH4_HUMAN | Histamine H4 receptor | Histamine H4 receptor (H4R) | Histamine receptor (H3 and H4) | Pfi-013 | SP9144
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44517.02
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH4R receptors.
Residue:
390
Sequence:
MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
  
Inhibitor
Name:
BDBM50261036
Synonyms:
(E)-{amino[(Z)-2-(1-{12-[(1Z)-1-(2-methylcarbamimidamidoimino)ethyl]-8-thiatricyclo[7.4.0.0^{2,7}]trideca-1(9),2(7),3,5,10,12-hexaen-4-yl}ethylidene)hydrazin-1-yl]methylidene}(methyl)azanium
Type:
Small organic molecule
Emp. Form.:
C20H25N8S
Mol. Mass.:
409.531
SMILES:
CNC(N)=NN=C(C)c1ccc2sc3ccc(cc3c2c1)C(C)=N[NH+]=C(N)NC |w:5.4,2.2,23.26,25.28|
Structure:
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