Reaction Details
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Fibroblast growth factor 2
Ligand
BDBM50260260
Substrate
n/a
Meas. Tech.
ChEMBL_508505 (CHEMBL1003199)
IC50
20000±n/a nM
Citation
Elson-Schwab, L; Garner, OB; Schuksz, M; Crawford, BE; Esko, JD; Tor, Y Guanidinylated neomycin delivers large, bioactive cargo into cells through a heparan sulfate-dependent pathway. J Biol Chem 282:13585-91 (2007) [PubMed] Article More Info.:
Target
Name:
Fibroblast growth factor 2
Synonyms:
Basic fibroblast growth factor | FGF-2 | FGF2 | FGF2_HUMAN | FGFB | Fibroblast growth factor 2 (bFGF) | Fibroblast growth factor receptor 2 (FGF-2) | HBGF-2 | Heparin-binding growth factor 2
Type:
Protein
Mol. Mass.:
30803.89
Organism:
Homo sapiens (Human)
Description:
P09038
Residue:
288
Sequence:
MVGVGGGDVEDVTPRPGGCQISGRGARGCNGIPGAAAWEAALPRRRPRRHPSVNPRSRAAGSPRTRGRRTEERPSGSRLGDRGRGRALPGGRLGGRGRGRAPERVGGRGRGRGTAAPRAAPAARGSRPGPAGTMAAGSITTLPALPEDGGSGAFPPGHFKDPKRLYCKNGGFFLRIHPDGRVDGVREKSDPHIKLQLQAEERGVVSIKGVCANRYLAMKEDGRLLASKCVTDECFFFERLESNNYNTYRSRKYTSWYVALKRTGQYKLGSKTGPGQKAILFLPMSAKS
Inhibitor
Name:
BDBM50260260
Synonyms:
Biotin-Ala-(Arg)9 | CID44576236 | [amino({[(1R,2S,3R,4R,5S)-5-{[amino(iminiumyl)methyl]amino}-4-{[(2R,3R,4R,5S,6R)-3-{[amino(iminiumyl)methyl]amino}-6-({[amino(iminiumyl)methyl]amino}methyl)-4,5-dihydroxyoxan-2-yl]oxy}-3-{[(2S,3R,4S,5R)-4-{[(2R,3R,4R,5S,6S)-3-{[amino(iminiumyl)methyl]amino}-6-({[amino(iminiumyl)methyl]amino}methyl)-4,5-dihydroxyoxan-2-yl]oxy}-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy}-2-hydroxycyclohexyl]amino})methylidene]azanium
Type:
Small organic molecule
Emp. Form.:
C29H64N18O13
Mol. Mass.:
872.928
SMILES:
[#7]-[#6](=[#7+])-[#7]-[#6]-[#6]-1-[#8]-[#6](-[#8]-[#6]-2-[#6](-[#6]-[#8])-[#8]-[#6](-[#8]-[#6]-3-[#6](-[#8])-[#6](-[#6]-[#6](\[#7+]=[#6](/[#7])-[#7])-[#6]-3-[#8]-[#6]-3-[#8]-[#6](-[#6]-[#7]-[#6](-[#7])=[#7+])-[#6](-[#8])-[#6](-[#8])-[#6]-3\[#7+]=[#6](\[#7])-[#7])\[#7+]=[#6](\[#7])-[#7])-[#6]-2-[#8])-[#6](-[#7]-[#6](-[#7])=[#7+])-[#6](-[#8])-[#6]-1-[#8]
Structure:
