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Target
Glycylpeptide N-tetradecanoyltransferase
Ligand
BDBM50034993
Substrate
n/a
Meas. Tech.
ChEMBL_507080 (CHEMBL946589)
IC50
24±n/a nM
Citation
 Wu, J; Tao, Y; Zhang, M; Howard, MH; Gutteridge, S; Ding, J Crystal structures of Saccharomyces cerevisiae N-myristoyltransferase with bound myristoyl-CoA and inhibitors reveal the functional roles of the N-terminal region. J Biol Chem 282:22185-94 (2007) [PubMed]  Article 
Target
Name:
Glycylpeptide N-tetradecanoyltransferase
Synonyms:
CDC72 | NMT1 | NMT_YEAST
Type:
PROTEIN
Mol. Mass.:
52840.42
Organism:
Saccharomyces cerevisiae
Description:
ChEMBL_507080
Residue:
455
Sequence:
MSEEDKAKKLENLLKLLQLNNDDTSKFTQEQKKAMKDHKFWRTQPVKDFDEKVVEEGPIDKPKTPEDISDKPLPLLSSFEWCSIDVDNKKQLEDVFVLLNENYVEDRDAGFRFNYTKEFFNWALKSPGWKKDWHIGVRVKETQKLVAFISAIPVTLGVRGKQVPSVEINFLCVHKQLRSKRLTPVLIKEITRRVNKCDIWHALYTAGIVLPAPVSTCRYTHRPLNWKKLYEVDFTGLPDGHTEEDMIAENALPAKTKTAGLRKLKKEDIDQVFELFKRYQSRFELIQIFTKEEFEHNFIGEESLPLDKQVIFSYVVEQPDGKITDFFSFYSLPFTILNNTKYKDLGIGYLYYYATDADFQFKDRFDPKATKALKTRLCELIYDACILAKNANMDVFNALTSQDNTLFLDDLKFGPGDGFLNFYLFNYRAKPITGGLNPDNSNDIKRRSNVGVVML
  
Inhibitor
Name:
BDBM50034993
Synonyms:
(S)-6-Amino-2-[(S)-3-hydroxy-2-(2-{4-[4-(2-methyl-imidazol-1-yl)-butyl]-phenyl}-acetylamino)-propionylamino]-hexanoic acid (2-cyclohexyl-ethyl)-amide | CHEMBL6269 | SC-58272 | [CYCLOHEXYLETHYL]-[[[[4-[2-METHYL-1-IMIDAZOLYL-BUTYL]PHENYL]ACETYL]-SERYL]-LYSINYL]-AMINE
Type:
Small organic molecule
Emp. Form.:
C33H52N6O4
Mol. Mass.:
596.8038
SMILES:
Cc1nccn1CCCCc1ccc(CC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)NCCC2CCCCC2)cc1
Structure:
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