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Target
Glycylpeptide N-tetradecanoyltransferase
Ligand
BDBM50270015
Substrate
n/a
Meas. Tech.
ChEMBL_507080 (CHEMBL946589)
IC50
50±n/a nM
Citation
 Wu, J; Tao, Y; Zhang, M; Howard, MH; Gutteridge, S; Ding, J Crystal structures of Saccharomyces cerevisiae N-myristoyltransferase with bound myristoyl-CoA and inhibitors reveal the functional roles of the N-terminal region. J Biol Chem 282:22185-94 (2007) [PubMed]  Article 
Target
Name:
Glycylpeptide N-tetradecanoyltransferase
Synonyms:
CDC72 | NMT1 | NMT_YEAST
Type:
PROTEIN
Mol. Mass.:
52840.42
Organism:
Saccharomyces cerevisiae
Description:
ChEMBL_507080
Residue:
455
Sequence:
MSEEDKAKKLENLLKLLQLNNDDTSKFTQEQKKAMKDHKFWRTQPVKDFDEKVVEEGPIDKPKTPEDISDKPLPLLSSFEWCSIDVDNKKQLEDVFVLLNENYVEDRDAGFRFNYTKEFFNWALKSPGWKKDWHIGVRVKETQKLVAFISAIPVTLGVRGKQVPSVEINFLCVHKQLRSKRLTPVLIKEITRRVNKCDIWHALYTAGIVLPAPVSTCRYTHRPLNWKKLYEVDFTGLPDGHTEEDMIAENALPAKTKTAGLRKLKKEDIDQVFELFKRYQSRFELIQIFTKEEFEHNFIGEESLPLDKQVIFSYVVEQPDGKITDFFSFYSLPFTILNNTKYKDLGIGYLYYYATDADFQFKDRFDPKATKALKTRLCELIYDACILAKNANMDVFNALTSQDNTLFLDDLKFGPGDGFLNFYLFNYRAKPITGGLNPDNSNDIKRRSNVGVVML
  
Inhibitor
Name:
BDBM50270015
Synonyms:
(S-(2-oxo)pentadecyl-CoA) | CHEMBL448516
Type:
Small organic molecule
Emp. Form.:
C36H64N7O17P3S
Mol. Mass.:
991.916
SMILES:
CCCCCCCCCCCCCC(=O)CSCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)n1cnc2c(N)ncnc12 |r|
Structure:
Search PDB for entries with ligand similarity: