Reaction Details Report a problem with these data
Target
Neutrophil elastase
Ligand
BDBM19516
Substrate
n/a
Meas. Tech.
ChEMBL_508157 (CHEMBL1008215)
IC50
25500±n/a nM
Citation
 Méthot, N; Rubin, J; Guay, D; Beaulieu, C; Ethier, D; Reddy, TJ; Riendeau, D; Percival, MD Inhibition of the activation of multiple serine proteases with a cathepsin C inhibitor requires sustained exposure to prevent pro-enzyme processing. J Biol Chem 282:20836-46 (2007) [PubMed]  Article 
Target
Name:
Neutrophil elastase
Synonyms:
ELNE_MOUSE | Ela2 | Elane
Type:
PROTEIN
Mol. Mass.:
28661.19
Organism:
Mus musculus
Description:
ChEMBL_1463437
Residue:
265
Sequence:
MALGRLSSRTLAAMLLALFLGGPALASEIVGGRPARPHAWPFMASLQRRGGHFCGATLIARNFVMSAAHCVNGLNFRSVQVVLGAHDLRRQERTRQTFSVQRIFENGFDPSQLLNDIVIIQLNGSATINANVQVAQLPAQGQGVGDRTPCLAMGWGRLGTNRPSPSVLQELNVTVVTNMCRRRVNVCTLVPRRQAGICFGDSGGPLVCNNLVQGIDSFIRGGCGSGLYPDAFAPVAEFADWINSIIRSHNDHLLTHPKDREGRTN
  
Inhibitor
Name:
BDBM19516
Synonyms:
(2S)-N-[(3S,5E)-6-(benzenesulfonyl)-4-oxo-1-phenylhex-5-en-3-yl]-4-methyl-2-(morpholin-4-ylcarbonylamino)pentanamide | CHEMBL222649 | LHVS | Morpholinurea-Leu-Hph-Vinyl-Sulfone-Phenyl | Morpholinurea-Leucine-Homophenylalaninevinyl Phenyl Sulfone
Type:
Small organic molecule
Emp. Form.:
C28H37N3O5S
Mol. Mass.:
527.675
SMILES:
CC(C)C[C@@H](NC(=O)N1CCOCC1)C(=O)N[C@H](CCc1ccccc1)C=CS(=O)(=O)c1ccccc1 |r,w:27.29|
Structure:
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