Reaction Details Report a problem with these data
Target
Delta-type opioid receptor
Ligand
BDBM50269338
Substrate
n/a
Meas. Tech.
ChEMBL_526494 (CHEMBL975645)
IC50
75400±n/a nM
Citation
 Katavic, PL; Venables, DA; Forster, PI; Guymer, G; Carroll, AR Grandisines C-G, indolizidine alkaloids from the Australian rainforest tree Elaeocarpus grandis. J Nat Prod 69:1295-9 (2006) [PubMed]  Article 
Target
Name:
Delta-type opioid receptor
Synonyms:
D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40382.98
Organism:
Homo sapiens (Human)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor.
Residue:
372
Sequence:
MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTACTPSDGPGGGAAA
  
Inhibitor
Name:
BDBM50269338
Synonyms:
Grandisine G
Type:
Small organic molecule
Emp. Form.:
C17H27N2O2
Mol. Mass.:
291.4079
SMILES:
COC(=O)C[C@@H]1C[C@H](C)CC(=N1)C1=CCC[NH+]2CCCC12 |r,c:10,t:13|
Structure:
Search PDB for entries with ligand similarity: