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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50251923
Substrate
n/a
Meas. Tech.
ChEMBL_488009 (CHEMBL1013888)
IC50
31±n/a nM
Citation
 Laufer, SA; Hauser, DR; Domeyer, DM; Kinkel, K; Liedtke, AJ Design, synthesis, and biological evaluation of novel Tri- and tetrasubstituted imidazoles as highly potent and specific ATP-mimetic inhibitors of p38 MAP kinase: focus on optimized interactions with the enzyme's surface-exposed front region. J Med Chem 51:4122-49 (2008) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50251923
Synonyms:
CHEMBL481750 | cis-{4-[4-(4-Fluoro-phenyl)-2-methylsulfanyl-1H-imidazol-5-yl]-pyridin-2-yl}-(4-methylcyclohexyl)-amine
Type:
Small organic molecule
Emp. Form.:
C22H25FN4S
Mol. Mass.:
396.524
SMILES:
CSc1nc(c([nH]1)-c1ccc(F)cc1)-c1ccnc(N[C@@H]2CC[C@H](C)CC2)c1 |r,wU:20.21,23.25,(43.41,-32.21,;42.64,-30.87,;41.1,-30.87,;40.19,-32.11,;38.73,-31.63,;38.73,-30.09,;40.2,-29.62,;37.4,-29.32,;37.42,-27.77,;36.09,-26.99,;34.75,-27.76,;33.42,-26.98,;34.74,-29.3,;36.07,-30.08,;37.4,-32.4,;36.06,-31.62,;34.73,-32.39,;34.73,-33.93,;36.07,-34.7,;36.08,-36.24,;37.42,-37.02,;37.44,-38.55,;38.77,-39.32,;40.1,-38.55,;41.43,-39.32,;40.1,-37.01,;38.76,-36.24,;37.4,-33.93,)|
Structure:
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