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Target
Carbonic anhydrase 5B, mitochondrial
Ligand
BDBM50261759
Substrate
n/a
Meas. Tech.
ChEMBL_514689 (CHEMBL976461)
Ki
10.5±n/a nM
Citation
 Poulsen, SA; Wilkinson, BL; Innocenti, A; Vullo, D; Supuran, CT Inhibition of human mitochondrial carbonic anhydrases VA and VB with para-(4-phenyltriazole-1-yl)-benzenesulfonamide derivatives. Bioorg Med Chem Lett 18:4624-7 (2008) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 5B, mitochondrial
Synonyms:
CA-VB | CA5B | CAH5B_HUMAN | Carbonate dehydratase VB | Carbonic Anhydrase VB | Carbonic anhydrase 5B (CA VB) | Carbonic anhydrase 5B, mitochondrial | Carbonic anhydrase 5B, mitochondrial precursor | Carbonic anhydrase V | Carbonic anhydrase VB (CA VB)
Type:
Enzyme
Mol. Mass.:
36440.83
Organism:
Homo sapiens (Human)
Description:
Human (cloned) isozyme
Residue:
317
Sequence:
MVVMNSLRVILQASPGKLLWRKFQIPRFMPARPCSLYTCTYKTRNRALHPLWESVDLVPGGDRQSPINIRWRDSVYDPGLKPLTISYDPATCLHVWNNGYSFLVEFEDSTDKSVIKGGPLEHNYRLKQFHFHWGAIDAWGSEHTVDSKCFPAELHLVHWNAVRFENFEDAALEENGLAVIGVFLKLGKHHKELQKLVDTLPSIKHKDALVEFGSFDPSCLMPTCPDYWTYSGSLTTPPLSESVTWIIKKQPVEVDHDQLEQFRTLLFTSEGEKEKRMVDNFRPLQPLMNRTVRSSFRHDYVLNVQAKPKPATSQATP
  
Inhibitor
Name:
BDBM50261759
Synonyms:
4-(4-(4-methoxy-2-methylphenyl)-1H-1,2,3-triazol-1-yl)benzenesulfonamide | CHEMBL512809
Type:
Small organic molecule
Emp. Form.:
C16H16N4O3S
Mol. Mass.:
344.388
SMILES:
COc1ccc(-c2cn(nn2)-c2ccc(cc2)S(N)(=O)=O)c(C)c1
Structure:
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