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Target
Small conductance calcium-activated potassium channel protein 1
Ligand
BDBM50264020
Substrate
n/a
Meas. Tech.
ChEMBL_535548 (CHEMBL986174)
IC50
43±n/a nM
Citation
 Gentles, RG; Grant-Young, K; Hu, S; Huang, Y; Poss, MA; Andres, C; Fiedler, T; Knox, R; Lodge, N; Weaver, CD; Harden, DG Initial SAR studies on apamin-displacing 2-aminothiazole blockers of calcium-activated small conductance potassium channels. Bioorg Med Chem Lett 18:5316-9 (2008) [PubMed]  Article 
Target
Name:
Small conductance calcium-activated potassium channel protein 1
Synonyms:
KCNN1 | KCNN1_HUMAN | SK | Small conductance calcium-activated potassium channel protein 1 | Small conductance calcium-activated potassium channel protein 1 (KCa2.1)
Type:
Protein
Mol. Mass.:
60005.90
Organism:
Homo sapiens (Human)
Description:
Q92952
Residue:
543
Sequence:
MNSHSYNGSVGRPLGSGPGALGRDPPDPEAGHPPQPPHSPGLQVVVAKSEPARPSPGSPRGQPQDQDDDEDDEEDEAGRQRASGKPSNVGHRLGHRRALFEKRKRLSDYALIFGMFGIVVMVTETELSWGVYTKESLYSFALKCLISLSTAILLGLVVLYHAREIQLFMVDNGADDWRIAMTCERVFLISLELAVCAIHPVPGHYRFTWTARLAFTYAPSVAEADVDVLLSIPMFLRLYLLGRVMLLHSKIFTDASSRSIGALNKITFNTRFVMKTLMTICPGTVLLVFSISSWIIAAWTVRVCERYHDKQEVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKHTRLVKKPDQARVRKHQRKFLQAIHQAQKLRSVKIEQGKLNDQANTLTDLAKTQTVMYDLVSELHAQHEELEARLATLESRLDALGASLQALPGLIAQAIRPPPPPLPPRPGPGPQDQAARSSPCRWTPVAPSDCG
  
Inhibitor
Name:
BDBM50264020
Synonyms:
CHEMBL489770 | GNF-PF-4773 | N-(4-(pyridin-2-yl)thiazol-2-yl)pyridin-2-amine | TCMDC-124275 | US9034574, I
Type:
Small organic molecule
Emp. Form.:
C13H10N4S
Mol. Mass.:
254.31
SMILES:
N(c1nc(cs1)-c1ccccn1)c1ccccn1
Structure:
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