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Target
Translocator protein
Ligand
BDBM50274561
Substrate
n/a
Meas. Tech.
ChEMBL_537932 (CHEMBL983517)
Ki
0.86±n/a nM
Citation
 Denora, N; Laquintana, V; Pisu, MG; Dore, R; Murru, L; Latrofa, A; Trapani, G; Sanna, E 2-Phenyl-imidazo[1,2-a]pyridine compounds containing hydrophilic groups as potent and selective ligands for peripheral benzodiazepine receptors: synthesis, binding affinity and electrophysiological studies. J Med Chem 51:6876-88 (2008) [PubMed]  Article 
Target
Name:
Translocator protein
Synonyms:
Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo
Type:
Mitochondrion membrane protein
Mol. Mass.:
18945.84
Organism:
Rattus norvegicus (rat)
Description:
Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:
169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAMGYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVATATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
  
Inhibitor
Name:
BDBM50274561
Synonyms:
4-(2-(4-Chlorophenyl)-3-(2-(dipropylamino)-2-oxoethyl)imidazo[1,2-a]pyridin-8-ylamino)-4-oxobutanoate | CHEMBL483596
Type:
Small organic molecule
Emp. Form.:
C27H33ClN4O4
Mol. Mass.:
513.028
SMILES:
CCCN(CCC)C(=O)Cc1c(nc2c(NC(=O)CCC(=O)OCC)cccn12)-c1ccc(Cl)cc1
Structure:
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