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Target
Sodium-dependent serotonin transporter
Ligand
BDBM50274783
Substrate
n/a
Meas. Tech.
ChEMBL_536732 (CHEMBL984526)
IC50
47±n/a nM
Citation
 Hatzenbuhler, NT; Baudy, R; Evrard, DA; Failli, A; Harrison, BL; Lenicek, S; Mewshaw, RE; Saab, A; Shah, U; Sze, J; Zhang, M; Zhou, D; Chlenov, M; Kagan, M; Golembieski, J; Hornby, G; Lai, M; Smith, DL; Sullivan, KM; Schechter, LE; Andree, TH Advances toward new antidepressants with dual serotonin transporter and 5-HT1A receptor affinity within a class of 3-aminochroman derivatives. Part 2. J Med Chem 51:6980-7004 (2008) [PubMed]  Article 
Target
Name:
Sodium-dependent serotonin transporter
Synonyms:
5-HT Transporter | 5HT transporter | 5HTT | HTT | SC6A4_HUMAN | SERT | SLC6A4 | Serotonin Transporter (SERT) | Serotonin transporter (5HTT) | Serotonin transporter protein (SERT) | Sodium-dependent serotonin transporter (SERT) | Solute carrier family 6 member 4
Type:
Multi-pass membrane protein
Mol. Mass.:
70322.51
Organism:
Homo sapiens (Human)
Description:
P31645
Residue:
630
Sequence:
METTPLNSQKQLSACEDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTRHSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIITPGTFKERIIKSITPETPTEIPCGDIRLNAV
  
Inhibitor
Name:
BDBM50274783
Synonyms:
(3R)-(-)-8-Fluoro-3-{[3-(5-fluoro-1H-indol-3-yl)propyl](propyl)-amino}-N-methylchromane-5-carboxamide | CHEMBL457751
Type:
Small organic molecule
Emp. Form.:
C25H29F2N3O2
Mol. Mass.:
441.5135
SMILES:
CCCN(CCCc1c[nH]c2ccc(F)cc12)[C@H]1COc2c(F)ccc(C(=O)NC)c2C1 |r|
Structure:
Search PDB for entries with ligand similarity: