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Target
Purine nucleoside phosphorylase
Ligand
BDBM50246591
Substrate
n/a
Meas. Tech.
ChEMBL_557942 (CHEMBL963040)
Ki
5.8±n/a nM
Citation
 Murkin, AS; Clinch, K; Mason, JM; Tyler, PC; Schramm, VL Immucillins in custom catalytic-site cavities. Bioorg Med Chem Lett 18:5900-3 (2008) [PubMed]  Article 
Target
Name:
Purine nucleoside phosphorylase
Synonyms:
Inosine phosphorylase | Inosine-guanosine phosphorylase | NP | PNP | PNPH_HUMAN | Purine nucleoside phosphorylase (PNPase)
Type:
Enzyme
Mol. Mass.:
32119.53
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
289
Sequence:
MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS
  
Inhibitor
Name:
BDBM50246591
Synonyms:
(+/-)-5'-deoxy-4'-fluoro-5'-methylthio-DADMe-ImmH | CHEMBL461527
Type:
Small organic molecule
Emp. Form.:
C13H17FN4O2S
Mol. Mass.:
312.363
SMILES:
CSC[C@@]1(F)CN(Cc2c[nH]c3c2nc[nH]c3=O)C[C@@H]1O |r|
Structure:
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