Reaction Details Report a problem with these data
Target
Purine nucleoside phosphorylase
Ligand
BDBM50247150
Substrate
n/a
Meas. Tech.
ChEMBL_557942 (CHEMBL963040)
Ki
160±n/a nM
Citation
 Murkin, AS; Clinch, K; Mason, JM; Tyler, PC; Schramm, VL Immucillins in custom catalytic-site cavities. Bioorg Med Chem Lett 18:5900-3 (2008) [PubMed]  Article 
Target
Name:
Purine nucleoside phosphorylase
Synonyms:
Inosine phosphorylase | Inosine-guanosine phosphorylase | NP | PNP | PNPH_HUMAN | Purine nucleoside phosphorylase (PNPase)
Type:
Enzyme
Mol. Mass.:
32119.53
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
289
Sequence:
MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS
  
Inhibitor
Name:
BDBM50247150
Synonyms:
5'-phenylthio-ImmH | CHEMBL474328 | US9290501, (B)
Type:
Small organic molecule
Emp. Form.:
C17H18N4O3S
Mol. Mass.:
358.415
SMILES:
O[C@@H]1[C@@H](CSc2ccccc2)N[C@H]([C@@H]1O)c1c[nH]c2c1nc[nH]c2=O |r|
Structure:
Search PDB for entries with ligand similarity: