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Target
3-oxoacyl-[acyl-carrier-protein] synthase 3
Ligand
BDBM50245878
Substrate
n/a
Meas. Tech.
ChEMBL_559691 (CHEMBL1010089)
IC50
3.76±n/a nM
Citation
 Alhamadsheh, MM; Waters, NC; Sachdeva, S; Lee, P; Reynolds, KA Synthesis and biological evaluation of novel sulfonyl-naphthalene-1,4-diols as FabH inhibitors. Bioorg Med Chem Lett 18:6402-5 (2008) [PubMed]  Article 
Target
Name:
3-oxoacyl-[acyl-carrier-protein] synthase 3
Synonyms:
β-Ketoacyl-acyl carrier protein (ACP) synthase III (FabH) | 3-oxoacyl-[acyl-carrier-protein] synthase III | FABH_MYCTU | fabH
Type:
Enzyme
Mol. Mass.:
34865.07
Organism:
Mycobacterium tuberculosis
Description:
P9WNG3
Residue:
335
Sequence:
MTEIATTSGARSVGLLSVGAYRPERVVTNDEICQHIDSSDEWIYTRTGIKTRRFAADDESAASMATEACRRALSNAGLSAADIDGVIVTTNTHFLQTPPAAPMVAASLGAKGILGFDLSAGCAGFGYALGAAADMIRGGGAATMLVVGTEKLSPTIDMYDRGNCFIFADGAAAVVVGETPFQGIGPTVAGSDGEQADAIRQDIDWITFAQNPSGPRPFVRLEGPAVFRWAAFKMGDVGRRAMDAAGVRPDQIDVFVPHQANSRINELLVKNLQLRPDAVVANDIEHTGNTSAASIPLAMAELLTTGAAKPGDLALLIGYGAGLSYAAQVVRMPKG
  
Inhibitor
Name:
BDBM50245878
Synonyms:
CHEMBL512926 | N-(4-(1,4-dihydroxynaphthalen-2-ylsulfonyl)phenyl)acetamide
Type:
Small organic molecule
Emp. Form.:
C18H15NO5S
Mol. Mass.:
357.38
SMILES:
CC(=O)Nc1ccc(cc1)S(=O)(=O)c1cc(O)c2ccccc2c1O
Structure:
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