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Target
Translocator protein
Ligand
BDBM50253776
Substrate
n/a
Meas. Tech.
ChEMBL_511514 (CHEMBL980957)
Ki
1.33±n/a nM
Citation
 Da Settimo, F; Simorini, F; Taliani, S; La Motta, C; Marini, AM; Salerno, S; Bellandi, M; Novellino, E; Greco, G; Cosimelli, B; Da Pozzo, E; Costa, B; Simola, N; Morelli, M; Martini, C Anxiolytic-like effects of N,N-dialkyl-2-phenylindol-3-ylglyoxylamides by modulation of translocator protein promoting neurosteroid biosynthesis. J Med Chem 51:5798-806 (2008) [PubMed]  Article 
Target
Name:
Translocator protein
Synonyms:
Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo
Type:
Mitochondrion membrane protein
Mol. Mass.:
18945.84
Organism:
Rattus norvegicus (rat)
Description:
Competitive binding experiments were performed on rat kidney mitochondrial membranes.
Residue:
169
Sequence:
MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAMGYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVATATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
  
Inhibitor
Name:
BDBM50253776
Synonyms:
CHEMBL461416 | N-benzyl-N-ethyl-2-(5-fluoro-2-phenyl-1H-indol-3-yl)-2-oxoacetamide
Type:
Small organic molecule
Emp. Form.:
C25H21FN2O2
Mol. Mass.:
400.4448
SMILES:
CCN(Cc1ccccc1)C(=O)C(=O)c1c([nH]c2ccc(F)cc12)-c1ccccc1
Structure:
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