Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50170660
Substrate
n/a
Meas. Tech.
ChEMBL_496794 (CHEMBL1008807)
Ki
2.38±n/a nM
Citation
 Cao, J; Kopajtic, T; Katz, JL; Newman, AH Dual DAT/sigma1 receptor ligands based on 3-(4-(3-(bis(4-fluorophenyl)amino)propyl)piperazin-1-yl)-1-phenylpropan-1-ol. Bioorg Med Chem Lett 18:5238-41 (2008) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50170660
Synonyms:
CHEMBL190883 | CHEMBL521582 | N,N-dipropyl-2-[4-methoxy-3-(2-phenylethoxy)phenyl]ethylamine | N-(4-methoxy-3-phenethoxyphenethyl)-N-propylpropan-1-amine | NE-100 | [2-(4-Methoxy-3-phenethyloxy-phenyl)-ethyl]-dipropyl-amine
Type:
Small organic molecule
Emp. Form.:
C23H33NO2
Mol. Mass.:
355.5136
SMILES:
CCCN(CCC)CCc1ccc(OC)c(OCCc2ccccc2)c1
Structure:
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