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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50248927
Substrate
n/a
Meas. Tech.
ChEMBL_578681 (CHEMBL1063062)
Ki
258±n/a nM
Citation
 Zampieri, D; Mamolo, MG; Laurini, E; Florio, C; Zanette, C; Fermeglia, M; Posocco, P; Paneni, MS; Pricl, S; Vio, L Synthesis, biological evaluation, and three-dimensional in silico pharmacophore model for sigma(1) receptor ligands based on a series of substituted benzo[d]oxazol-2(3H)-one derivatives. J Med Chem 52:5380-93 (2009) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Opioid receptor | Oprs1 | SGMR1_RAT | Sigma | Sigma non-opioid intracellular receptor 1 | Sigma opioid receptor | Sigma-1 | Sigmar1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25266.54
Organism:
RAT
Description:
Q9R0C9
Residue:
223
Sequence:
MPWAVGRRWAWITLFLTIVAVLIQAVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSHGHSGRYWAEISDTIISGTFHQWREGTTKSEVYYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALSDTIFSTQDFLTLFYTLRAYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50248927
Synonyms:
3-((1-(2,4-dichlorobenzyl)piperidin-4-yl)methyl)benzo[d]oxazol-2(3H)-one | 3-[[1-(2,4-Dichlorobenzyl)piperidin-4-yl]methyl]benzo[d]oxazol-2(3H)-one | CHEMBL473975
Type:
Small organic molecule
Emp. Form.:
C20H20Cl2N2O2
Mol. Mass.:
391.291
SMILES:
Clc1ccc(CN2CCC(Cn3c4ccccc4oc3=O)CC2)c(Cl)c1
Structure:
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